Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors (Q37183072): Difference between revisions

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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors
label / nllabel / nl
 
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.
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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors
description / frdescription / fr
article scientifique
article scientifique publié en 2016
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artigo científico
artigo científico (publicado na 2016)
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videnskabelig artikel
videnskabelig artikel (udgivet 2016)
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наукова стаття, опублікована в лютому 2016
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artículu científicu espublizáu en 2016
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научна статия
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২০১৬-এ প্রকাশিত বৈজ্ঞানিক নিবন্ধ
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επιστημονικό άρθρο
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scienca artikolo
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artículo científico publicado en 2016
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مقالهٔ علمی
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tieteellinen artikkeli
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tudományos cikk
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2016年の論文
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სამეცნიერო სტატია
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2016년 논문
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mokslinis straipsnis
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2016 nî lūn-bûn
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article scientific
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artykuł naukowy
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artigo científico (publicado na 2016)
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articol științific
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научная статья
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artikull shkencor
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мақолаи илмӣ
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سائنسی مضمون
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bài báo khoa học
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2016年学术文章
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2016年學術文章
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2016年学术文章
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2016年学术文章
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2016年學術文章
Property / titleProperty / title
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors. (English)
Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors (English)
Property / author name string
Craig W Lindsley
 
Property / author name string: Craig W Lindsley / rank
Normal rank
 
Property / author name string: Craig W Lindsley / qualifier
 
Property / author name string: Craig W Lindsley / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
Timestamp+2017-08-18T00:00:00Z
Timezone+00:00
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Property / author name string
Kyle A Emmitte
 
Property / author name string: Kyle A Emmitte / rank
Normal rank
 
Property / author name string: Kyle A Emmitte / qualifier
 
Property / author name string: Kyle A Emmitte / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
Timestamp+2017-08-18T00:00:00Z
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Property / author name string
Corey R Hopkins
 
Property / author name string: Corey R Hopkins / rank
Normal rank
 
Property / author name string: Corey R Hopkins / qualifier
 
Property / author name string: Corey R Hopkins / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
Timestamp+2017-08-18T00:00:00Z
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Property / author name string
Karen J Gregory
 
Property / author name string: Karen J Gregory / rank
Normal rank
 
Property / author name string: Karen J Gregory / qualifier
 
Property / author name string: Karen J Gregory / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
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Property / author name string
Colleen M Niswender
 
Property / author name string: Colleen M Niswender / rank
Normal rank
 
Property / author name string: Colleen M Niswender / qualifier
 
Property / author name string: Colleen M Niswender / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
Timestamp+2017-08-18T00:00:00Z
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Property / author name string
P Jeffrey Conn
 
Property / author name string: P Jeffrey Conn / rank
Normal rank
 
Property / author name string: P Jeffrey Conn / qualifier
 
Property / author name string: P Jeffrey Conn / reference
stated in: Europe PubMed Central
PMC publication ID: 4988345
retrieved: 18 August 2017
Timestamp+2017-08-18T00:00:00Z
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Property / cites work
 
Property / cites work: A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. / rank
 
Normal rank
Property / cites work: A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. / reference
 
Property / cites work
 
Property / cites work: Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type / rank
 
Normal rank
Property / cites work: Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild Type / reference
 
Property / cites work
 
Property / cites work: Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. / rank
 
Normal rank
Property / cites work: Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. / reference
 
Property / cites work
 
Property / cites work: A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators / rank
 
Normal rank
Property / cites work: A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators / reference
 
Property / cites work
 
Property / cites work: Molecular mechanisms of sweet receptor function. / rank
 
Normal rank
Property / cites work: Molecular mechanisms of sweet receptor function. / reference
 
Property / cites work
 
Property / cites work: Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. / rank
 
Normal rank
Property / cites work: Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. / reference
 
Property / cites work
 
Property / cites work: GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. / rank
 
Normal rank
Property / cites work: GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. / reference
 
Property / cites work
 
Property / cites work: Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia / rank
 
Normal rank
Property / cites work: Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia / reference
 
Property / cites work
 
Property / cites work: Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case-control and familial samples / rank
 
Normal rank
Property / cites work: Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case-control and familial samples / reference
 
Property / cites work
 
Property / cites work: Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / rank
 
Normal rank
Property / cites work: Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). / reference
 
Property / cites work
 
Property / cites work: Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action. / rank
 
Normal rank
Property / cites work: Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action. / reference
 
Property / cites work
 
Property / cites work: Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs / rank
 
Normal rank
Property / cites work: Synthesis and SAR of substituted pyrazolo[1,5-a]quinazolines as dual mGlu(2)/mGlu(3) NAMs / reference
 
Property / cites work
 
Property / cites work: Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia? / rank
 
Normal rank
Property / cites work: Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia? / reference
 
Property / cites work
 
Property / cites work: Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism / rank
 
Normal rank
Property / cites work: Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism / reference
 
Property / cites work
 
Property / cites work: A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease / rank
 
Normal rank
Property / cites work: A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease / reference
 
Property / cites work
 
Property / cites work: Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia / rank
 
Normal rank
Property / cites work: Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia / reference
 
Property / cites work
 
Property / cites work: Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor / rank
 
Normal rank
Property / cites work: Discovery of 1,4-disubstituted 3-cyano-2-pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor / reference
 
Property / cites work
 
Property / cites work: Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists / rank
 
Normal rank
Property / cites work: Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists / reference
 
Property / cites work
 
Property / cites work: mGluR2-Positive allosteric modulators: Therapeutic potential for treating cocaine abuse? / rank
 
Normal rank
Property / cites work: mGluR2-Positive allosteric modulators: Therapeutic potential for treating cocaine abuse? / reference
 
Property / cites work
 
Property / cites work: Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder / rank
 
Normal rank
Property / cites work: Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder / reference
 
Property / cites work
 
Property / cites work: Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes / rank
 
Normal rank
Property / cites work: Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes / reference
 
Property / cites work
 
Property / cites work: Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism. / rank
 
Normal rank
Property / cites work: Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism. / reference
 
Property / cites work
 
Property / cites work: Operational models of pharmacological agonism. / rank
 
Normal rank
Property / cites work: Operational models of pharmacological agonism. / reference
 
Property / cites work
 
Property / cites work: Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function / rank
 
Normal rank
Property / cites work: Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function / reference
 
Property / cites work
 
Property / cites work: Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus / rank
 
Normal rank
Property / cites work: Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus / reference
 
Property / cites work
 
Property / cites work: Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition / rank
 
Normal rank
Property / cites work: Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition / reference
 
Property / cites work
 
Property / cites work: Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. / rank
 
Normal rank
Property / cites work: Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. / reference
 
Property / cites work
 
Property / cites work: The metabotropic glutamate receptor subtype 7 rs3792452 polymorphism is associated with the response to methylphenidate in children with attention-deficit/hyperactivity disorder. / rank
 
Normal rank
Property / cites work: The metabotropic glutamate receptor subtype 7 rs3792452 polymorphism is associated with the response to methylphenidate in children with attention-deficit/hyperactivity disorder. / reference
 
Property / cites work
 
Property / cites work: mGlu(2) receptor-mediated modulation of conditioned avoidance behavior in rats / rank
 
Normal rank
Property / cites work: mGlu(2) receptor-mediated modulation of conditioned avoidance behavior in rats / reference
 
Property / cites work
 
Property / cites work: Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. / rank
 
Normal rank
Property / cites work: Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1. / reference
 
Property / cites work
 
Property / cites work: Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782. / rank
 
Normal rank
Property / cites work: Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782. / reference
 
Property / cites work
 
Property / cites work: Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. / rank
 
Normal rank
Property / cites work: Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor. / reference
 
Property / cites work
 
Property / cites work: mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice / rank
 
Normal rank
Property / cites work: mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice / reference
 
Property / cites work
 
Property / cites work: Effect of an mGlu2/3 receptor antagonist on depressive behavior induced by withdrawal from chronic treatment with methamphetamine / rank
 
Normal rank
Property / cites work: Effect of an mGlu2/3 receptor antagonist on depressive behavior induced by withdrawal from chronic treatment with methamphetamine / reference
 
Property / cites work
 
Property / cites work: Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands. / rank
 
Normal rank
Property / cites work: Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands. / reference
 
Property / cites work
 
Property / cites work: Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target / rank
 
Normal rank
Property / cites work: Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target / reference
 
Property / cites work
 
Property / cites work: Role of metabotropic glutamate receptor 7 in autism spectrum disorders: a pilot study / rank
 
Normal rank
Property / cites work: Role of metabotropic glutamate receptor 7 in autism spectrum disorders: a pilot study / reference
 
Property / cites work
 
Property / cites work: Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. / rank
 
Normal rank
Property / cites work: Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. / reference
 
Property / cites work
 
Property / cites work: Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging / rank
 
Normal rank
Property / cites work: Synthesis, evaluation, and radiolabeling of new potent positive allosteric modulators of the metabotropic glutamate receptor 2 as potential tracers for positron emission tomography imaging / reference
 
Property / cites work
 
Property / cites work: Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor / rank
 
Normal rank
Property / cites work: Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu₄ receptor / reference
 
Property / cites work
 
Property / cites work: Allosteric modulation of endogenous metabolites as an avenue for drug discovery. / rank
 
Normal rank
Property / cites work: Allosteric modulation of endogenous metabolites as an avenue for drug discovery. / reference
 
Property / cites work
 
Property / cites work: Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects / rank
 
Normal rank
Property / cites work: Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects / reference
 
Property / cites work
 
Property / cites work: A genome-wide significant linkage for severe depression on chromosome 3: the depression network study / rank
 
Normal rank
Property / cites work: A genome-wide significant linkage for severe depression on chromosome 3: the depression network study / reference
 
Property / cites work
 
Property / cites work: A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia / rank
 
Normal rank
Property / cites work: A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia / reference
 
Property / cites work
 
Property / cites work: The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? / rank
 
Normal rank
Property / cites work: The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? / reference
 
Property / cites work
 
Property / cites work: Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. / rank
 
Normal rank
Property / cites work: Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy. / reference
 
Property / cites work
 
Property / cites work: Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists / rank
 
Normal rank
Property / cites work: Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists / reference
 
Property / cites work
 
Property / cites work: Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one / rank
 
Normal rank
Property / cites work: Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4-ylethoxy)-4H-chromen-4-one / reference
 
Property / cites work
 
Property / cites work: Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia / rank
 
Normal rank
Property / cites work: Association study of polymorphisms in the group III metabotropic glutamate receptor genes, GRM4 and GRM7, with schizophrenia / reference
 
Property / cites work
 
Property / cites work: Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. / rank
 
Normal rank
Property / cites work: Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. / reference
 
Property / cites work
 
Property / cites work: Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039). / rank
 
Normal rank
Property / cites work: Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039). / reference
 
Property / cites work
 
Property / cites work: The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity / rank
 
Normal rank
Property / cites work: The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity / reference
 
Property / cites work
 
Property / cites work: The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats / rank
 
Normal rank
Property / cites work: The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats / reference
 
Property / cites work
 
Property / cites work: Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys / rank
 
Normal rank
Property / cites work: Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys / reference
 
Property / cites work
 
Property / cites work: Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors / rank
 
Normal rank
Property / cites work: Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors / reference
 
Property / cites work
 
Property / cites work: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. / rank
 
Normal rank
Property / cites work: Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. / reference
 
Property / cites work
 
Property / cites work: Analysis of allosterism in functional assays / rank
 
Normal rank
Property / cites work: Analysis of allosterism in functional assays / reference
 
Property / cites work
 
Property / cites work: 3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2). / rank
 
Normal rank
Property / cites work: 3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2). / reference
 
Property / cites work
 
Property / cites work: AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist / rank
 
Normal rank
Property / cites work: AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist / reference
 
Property / cites work
 
Property / cites work: Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results / rank
 
Normal rank
Property / cites work: Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results / reference
 
Property / cites work
 
Property / cites work: G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor / rank
 
Normal rank
Property / cites work: G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor / reference
 
Property / cites work
 
Property / cites work: Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons / rank
 
Normal rank
Property / cites work: Group III metabotropic glutamate-receptor-mediated modulation of excitatory transmission in rodent substantia nigra pars compacta dopamine neurons / reference
 
Property / cites work
 
Property / cites work: Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism. / rank
 
Normal rank
Property / cites work: Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism. / reference
 
Property / cites work
 
Property / cites work: Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. / rank
 
Normal rank
Property / cites work: Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer. / reference
 
Property / cites work
 
Property / cites work: Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent / rank
 
Normal rank
Property / cites work: Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent / reference
 
Property / cites work
 
Property / cites work: Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039. / rank
 
Normal rank
Property / cites work: Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039. / reference
 
Property / cites work
 
Property / cites work: Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity / rank
 
Normal rank
Property / cites work: Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity / reference
 
Property / cites work
 
Property / cites work: Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia / rank
 
Normal rank
Property / cites work: Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia / reference
 
Property / cites work
 
Property / cites work: [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor / rank
 
Normal rank
Property / cites work: [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor / reference
 
Property / cites work
 
Property / cites work: Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment / rank
 
Normal rank
Property / cites work: Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment / reference
 
Property / cites work
 
Property / cites work: The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam / rank
 
Normal rank
Property / cites work: The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam / reference
 
Property / cites work
 
Property / cites work: [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. / rank
 
Normal rank
Property / cites work: [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. / reference
 
Property / cites work
 
Property / cites work: Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices. / rank
 
Normal rank
Property / cites work: Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices. / reference
 
Property / cites work
 
Property / cites work: Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation. / rank
 
Normal rank
Property / cites work: Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation. / reference
 
Property / cites work
 
Property / cites work: Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties / rank
 
Normal rank
Property / cites work: Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties / reference
 
Property / cites work
 
Property / cites work: LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia / rank
 
Normal rank
Property / cites work: LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia / reference
 
Property / cites work
 
Property / cites work: Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells / rank
 
Normal rank
Property / cites work: Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells / reference
 
Property / cites work
 
Property / cites work: Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric m / rank
 
Normal rank
Property / cites work: Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric m / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia / rank
 
Normal rank
Property / cites work: A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo / rank
 
Normal rank
Property / cites work: Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3 / rank
 
Normal rank
Property / cites work: Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3 / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection / rank
 
Normal rank
Property / cites work: The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: Metabotropic glutamate receptor 5 is a disulfide-linked dimer / rank
 
Normal rank
Property / cites work: Metabotropic glutamate receptor 5 is a disulfide-linked dimer / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5 / rank
 
Normal rank
Property / cites work: Identification of glutathione conjugates of acetylene-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5 / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: 2014 prescription medications in the United States: tremendous growth, specialty/orphan drug expansion, and dispensed prescriptions continue to increase / rank
 
Normal rank
Property / cites work: 2014 prescription medications in the United States: tremendous growth, specialty/orphan drug expansion, and dispensed prescriptions continue to increase / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
Before0
After0

based on heuristic: inferred from PubMed ID database lookup
Property / cites work
 
Property / cites work: Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors / rank
 
Normal rank
Property / cites work: Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors / reference
 
stated in: PubMed
reference URL: https://pubmed.ncbi.nlm.nih.gov/26882314
retrieved: 12 December 2020
Timestamp+2020-12-12T00:00:00Z
Timezone+00:00
CalendarGregorian
Precision1 day
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based on heuristic: inferred from PubMed ID database lookup
Property / main subject
 
Property / main subject: G protein-coupled receptor / rank
 
Normal rank
Property / author
 
Property / author: Craig W. Lindsley / rank
 
Normal rank
Property / author: Craig W. Lindsley / qualifier
 
Property / author: Craig W. Lindsley / qualifier
 
object named as: Craig W Lindsley
Property / author: Craig W. Lindsley / reference
 
stated in: Europe PubMed Central
PMC publication ID: 4988345
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CalendarGregorian
Precision1 day
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Property / author: P. Jeffrey Conn / rank
 
Normal rank
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Property / author: P. Jeffrey Conn / qualifier
 
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Property / author: P. Jeffrey Conn / reference
 
stated in: Europe PubMed Central
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Property / author: Colleen M. Niswender / rank
 
Normal rank
Property / author: Colleen M. Niswender / qualifier
 
Property / author: Colleen M. Niswender / qualifier
 
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Property / author: Colleen M. Niswender / reference
 
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Property / author: Corey R. Hopkins / rank
 
Normal rank
Property / author: Corey R. Hopkins / qualifier
 
Property / author: Corey R. Hopkins / qualifier
 
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Property / author: Corey R. Hopkins / reference
 
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Property / author: Karen J. Gregory / rank
 
Normal rank
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Property / author: Karen J. Gregory / qualifier
 
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Property / author: Karen J. Gregory / reference
 
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Property / author: Kyle A. Emmitte / rank
 
Normal rank
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Property / author: Kyle A. Emmitte / reference
 
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Latest revision as of 02:30, 7 March 2024

scientific article published on 16 February 2016
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Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors
scientific article published on 16 February 2016

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    Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors (English)

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