mGlu5 negative allosteric modulators: a patent review (2010-2012). (Q38075897)

28 August 2017

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title

mGlu5 negative allosteric modulators: a patent review (2010-2012). (English)

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28 August 2017

Kyle A Emmitte

1

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28 August 2017

language of work or name

English

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publication date

22 January 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

published in

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28 August 2017

volume

23

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28 August 2017

issue

4

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28 August 2017

page(s)

393-408

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

28 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats

21 January 2018

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21 January 2018

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Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens

21 January 2018

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Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.

21 January 2018

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Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP

21 January 2018

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Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

21 January 2018

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Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study

21 January 2018

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A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

21 January 2018

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A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

21 January 2018

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Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?

21 January 2018

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

21 January 2018

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Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development

21 January 2018

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21 January 2018

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Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

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Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson's disease

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[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

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[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

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Evaluation of marble-burying behavior as a model of anxiety

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Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

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Digging and marble burying in mice: simple methods for in vivo identification of biological impacts.

21 January 2018

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Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

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Glutamate receptors in pediatric tumors of the central nervous system

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mGlu Receptors and Cancerous Growth

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

21 January 2018

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10.1517/13543776.2013.760544

21 January 2018

Identifiers

DOI

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28 August 2017

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