Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics (Q34795759)

25220431

4 August 2017

title

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics (English)

1 reference

4 August 2017

2

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1 June 2020

Karen J. Gregory

3

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1 June 2020

Sebastian Furness

4

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1 June 2020

Patrick M. Sexton

5

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1 June 2020

Peter J. Scammells

6

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1 June 2020

Arthur Christopoulos

8

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1 June 2020

Katherine Leach

9

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1 June 2020

author name string

A E Cook

1

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1 June 2020

A D Conigrave

7

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1 June 2020

language of work or name

English

0 references

publication date

1 December 2014

1 reference

25220431

British Journal of Pharmacology

4 August 2017

published in

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1 June 2020

volume

172

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1 June 2020

issue

1

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1 June 2020

page(s)

185-200

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describes a project that uses

1 June 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids.

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Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion

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Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion

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Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators

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Role of the cytoskeleton in extracellular calcium-regulated PTH release

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Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568.

26 October 2018

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Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism

26 October 2018

1 reference

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12 December 2020

Ca2+-induced increases in steady-state concentrations of intracellular calcium are not required for inhibition of parathyroid hormone secretion

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12 December 2020

Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism

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12 December 2020

Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis

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12 December 2020

The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine

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12 December 2020

Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism

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12 December 2020

NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium

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12 December 2020

Calcimimetic compound NPS R-568 stimulates calcitonin secretion but selectively targets parathyroid gland Ca(2+) receptor in rats

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12 December 2020

Identifiers

DOI

10.1111/BPH.12937

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25220431%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

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1 June 2020

25220431

1 reference