Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses (Q28548280)

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English	Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses	scientific article

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Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses (English)

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Takashi Nakakura

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Takashi Nakakura

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Takashi

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Nakakura

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13 June 2020

Mitsuhiro Arisawa

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13 June 2020

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Koichi Sato

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13 June 2020

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Ayaka Tobo

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13 June 2020

Masayuki Tobo

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13 June 2020

Masashi Ebara

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13 June 2020

Hideaki Tomura

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13 June 2020

Chihiro Mogi

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13 June 2020

Dong-Soon Im

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13 June 2020

Naoya Murata

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13 June 2020

Atsushi Kuwabara

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13 June 2020

Saki Ito

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13 June 2020

Hayato Fukuda

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13 June 2020

Satoshi Shuto

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13 June 2020

Michio Nakaya

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13 June 2020

Hitoshi Kurose

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13 June 2020

Fumikazu Okajima

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13 June 2020

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13 June 2020

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13 June 2020

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13 June 2020

e0129334

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13 June 2020

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12 June 2015

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Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

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Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis

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Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway

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Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms

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Prostaglandin I(2) production and cAMP accumulation in response to acidic extracellular pH through OGR1 in human aortic smooth muscle cells

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Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells

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Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways

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21 January 2018

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21 January 2018

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Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor

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https://pubmed.ncbi.nlm.nih.gov/26070068

12 December 2020

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Inhibition of interleukin-1β production by extracellular acidification through the TDAG8/cAMP pathway in mouse microglia

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12 December 2020

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13 June 2020

2015PLoSO..1029334T

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13 June 2020

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