Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. (Q39346114)

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1 February 2020

title

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM (English)

1 reference

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Mitchell Vamos

9

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Colleen M Niswender

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Craig W Lindsley

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P Jeffrey Conn

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Ryan D Morrison

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Shaun R Stauffer

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Douglas J Sheffler

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Kiran K Gogi

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Anna L Blobaum

1 reference

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author name string

Joshua A Bruner

3

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Sheridan J S Carrington

4

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Paige N Vinson

5

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Nicholas D P Cosford

10

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J Scott Daniels

12

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language of work or name

English

0 references

publication date

30 April 2012

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Bioorganic & Medicinal Chemistry Letters

1 February 2020

number of pages

5

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inferred from page(s)

published in

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volume

22

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issue

12

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page(s)

3921-3925

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Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

1 February 2020

cites work

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Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics

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Recent advances in the medicinal chemistry of the metabotropic glutamate receptor 1 (mGlu₁)

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Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

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"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

11 September 2017

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Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines

11 September 2017

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

11 September 2017

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

11 September 2017

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Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold

11 September 2017

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The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.

11 September 2017

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In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

11 September 2017

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Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?

11 September 2017

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Ionotropic and metabotropic glutamate receptor structure and pharmacology

11 September 2017

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Development of a custom high-throughput preparative liquid chromatography/mass spectrometer platform for the preparative purification and analytical analysis of compound libraries

11 September 2017

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

11 September 2017

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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

11 September 2017

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11 September 2017

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A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new insights into the pharmacology of the group III metabotropic glutamate receptors

11 September 2017

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Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

14 September 2017

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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

25 September 2017

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Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

17 June 2018

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

21 August 2018

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Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the treatment of depression: a new strategy to shorten the latency of antidepressant medication?

21 August 2018

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The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22607673

inferred from PubMed ID database lookup

12 December 2020

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Identifiers

DOI

10.1016/J.BMCL.2012.04.112

1 reference

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1 February 2020

1 reference

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1 February 2020

PubMed publication ID

22607673

1 reference