Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity (Q30535764)

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English	Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

15 August 2017

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity (English)

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15 August 2017

Colleen M. Niswender

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Colleen M Niswender

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15 August 2017

P. Jeffrey Conn

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P Jeffrey Conn

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15 August 2017

Craig W. Lindsley

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Craig W Lindsley

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15 August 2017

Karen J. Gregory

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Karen J Gregory

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15 August 2017

6

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Hyekyung P Cho

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15 August 2017

13

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Zixiu Xiang

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15 August 2017

Shaun R Stauffer

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Shaun R Stauffer

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15 August 2017

Meredith J Noetzel

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Meredith J Noetzel

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15 August 2017

Rocco G Gogliotti

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Rocco D Gogliotti

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15 August 2017

9

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Jason T Manka

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15 August 2017

16

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Carrie K Jones

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15 August 2017

author name string

Jerri M Rook

1

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15 August 2017

Wendy A Pouliot

3

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15 August 2017

Thomas M Bridges

4

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15 August 2017

Paige N Vinson

5

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15 August 2017

Ya Zhou

7

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15 August 2017

F Edward Dudek

12

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15 August 2017

J Scott Daniels

15

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15 August 2017

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publication date

7 November 2012

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15 August 2017

Biological Psychiatry

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15 August 2017

73

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PMC publication ID

15 August 2017

6

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Europe PubMed Central

PMC publication ID

15 August 2017

501-509

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Europe PubMed Central

PMC publication ID

15 August 2017

Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships

1 reference

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20 June 2018

Progress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).

1 reference

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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

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Mutations causing syndromic autism define an axis of synaptic pathophysiology

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Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.

1 reference

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20 June 2018

Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold

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Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

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20 June 2018

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

1 reference

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Molecular basis for amino acid sensing by family C G-protein-coupled receptors

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mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning

1 reference

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Cellular plasticity for group I mGluR-mediated epileptogenesis

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A simple quantitative method for analyzing electrographic status epilepticus in rats

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

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Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

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ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activiti

1 reference

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Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm

1 reference

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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

1 reference

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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

1 reference

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A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators

1 reference

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A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models

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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

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Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges

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1 reference

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Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges.

1 reference

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Receptor subtypes linked to metabotropic glutamate receptor agonist-mediated limbic seizures in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23140665

12 December 2020

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The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

1 reference

https://pubmed.ncbi.nlm.nih.gov/23140665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BIOPSYCH.2012.09.012

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

release_fbui4cmtnrafze7wqetl5rigtu

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https://api.fatcat.wiki/v0/release/fbui4cmtnrafze7wqetl5rigtu

24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

15 August 2017

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