Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges (Q35534556)

8 August 2017

title

Further optimization of the M5 NAM MLPCN probe ML375: tactics and challenges (English)

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8 August 2017

6

Colleen M Niswender

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8 August 2017

10

P Jeffrey Conn

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8 August 2017

11

Craig W Lindsley

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8 August 2017

2

Patrick R Gentry

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8 August 2017

4

Hyekyung P Cho

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8 August 2017

3

Masaya Kokubo

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8 August 2017

Haruto Kurata

1

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8 August 2017

Thomas M Bridges

5

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8 August 2017

Frank W Byers

7

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8 August 2017

Michael R Wood

8

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8 August 2017

J Scott Daniels

9

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8 August 2017

language of work or name

English

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publication date

13 December 2014

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Bioorganic & Medicinal Chemistry Letters

8 August 2017

number of pages

5

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based on heuristic

inferred from page(s)

published in

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8 August 2017

volume

25

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8 August 2017

issue

3

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8 August 2017

page(s)

690-694

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Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380)

8 August 2017

cites work

1 reference

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Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe

27 July 2018

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Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)

27 July 2018

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Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM)

27 July 2018

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Discovery of ML326: The first sub-micromolar, selective M5 PAM

27 July 2018

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Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

27 July 2018

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Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

27 July 2018

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Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators

27 July 2018

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Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor

27 July 2018

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Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

27 July 2018

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

27 July 2018

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Application of combinatorial chemistry science on modern drug discovery

27 July 2018

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Muscarinic acetylcholine receptors as CNS drug targets

27 July 2018

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

27 July 2018

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Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults

27 July 2018

1 reference

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Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.

27 July 2018

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Section I. The cholinergic system

27 July 2018

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Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia

27 July 2018

1 reference

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Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia

27 July 2018

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2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites

27 July 2018

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Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice.

26 September 2018

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26 September 2018

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26 September 2018

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Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain.

26 September 2018

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In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25542588

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BMCL.2014.11.082

1 reference

8 August 2017

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8 August 2017

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