Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q61809000)
Watch
English
Bivalent Ligands for Protein Degradation in Drug Discovery
scientific article published on 25 January 2019
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
title
Bivalent Ligands for Protein Degradation in Drug Discovery
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
main subject
drug discovery
1 reference
based on heuristic
inferred from title
author
Marcel Scheepstra
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
author name string
Luc van Hijfte
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
Koen F W Hekking
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
Rutger H A Folmer
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
publication date
25 January 2019
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
published in
Computational and Structural Biotechnology Journal
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
volume
17
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
page(s)
160-176
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
cites work
Cyclin is degraded by the ubiquitin pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Controlling signal transduction with synthetic ligands
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein kinase CK2: a challenge to canons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemical genetic control of protein levels: selective in vivo targeted degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Principles for modulation of the nuclear receptor superfamily
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Use of PROTACS as molecular probes of angiogenesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Drug discovery in the ubiquitin-proteasome system.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of the MDM2 antagonist nutlin-3 in human prostate cancer cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The selectivity of inhibitors of protein kinase CK2: an update
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemical control of protein stability and function in living mice.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting cancer with small molecule kinase inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Two-headed PROTAC: an effective new tool for targeted protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Scalable rule-based modelling of allosteric proteins and biochemical networks
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BET domain co-regulators in obesity, inflammation and cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Overexpression of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SIRT1 and SIRT2: emerging targets in neurodegeneration
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
On dihydroorotate dehydrogenases and their inhibitors and uses
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evaluation of WO2013076170: the use of a dihydroorotate dehydrogenase inhibitor for the treatment of psoriasis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bromodomains and their pharmacological inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular pathways: resistance to kinase inhibitors and implications for therapeutic strategies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The mechanisms behind the therapeutic activity of BET bromodomain inhibition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Choosing the Right Tool for the Job: RNAi, TALEN, or CRISPR.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Catalytic in vivo protein knockdown by small-molecule PROTACs.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of Chemical Inhibitors of Human Bromodomains
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting transcription factors by small compounds--Current strategies and future implications.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-Molecule PROTACS: New Approaches to Protein Degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bromodomain inhibitor OTX015 in patients with acute leukaemia: a dose-escalation, phase 1 study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BET Bromodomain as a Target of Epigenetic Therapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inside HDACs with more selective HDAC inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
New strategy for renal fibrosis: Targeting Smad3 proteins for ubiquitination and degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Clinical trials for BET inhibitors run ahead of the science
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Induced protein degradation: an emerging drug discovery paradigm
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted protein degradation by PROTACs
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structural basis of PROTAC cooperative recognition for selective protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Waste disposal-An attractive strategy for cancer therapy.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Delivery technologies for genome editing
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cooperative binding mitigates the high-dose hook effect.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Design, Synthesis, and Characterization of Brequinar Conjugates as Probes to Study DHODH Inhibition.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Trends in GPCR drug discovery: new agents, targets and indications.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-Molecule Kinase Downregulators
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The dTAG system for immediate and target-specific protein degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phthalimide conjugations for the degradation of oncogenic PI3K.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
An Overview on the Clinical Development of Tau-Based Therapeutics.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase using PROTAC-mediated Degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted protein degradation and the enzymology of degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Plasticity in binding confers selectivity in ligand-induced protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Delineating the role of cooperativity in the design of potent PROTACs for BTK.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Homo-PROTACs for the Chemical Knockdown of Cereblon
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin-proteasome pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Bromodomain Drug Discovery - the Past, the Present, and the Future
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting Brd4 for cancer therapy: inhibitors and degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Harnessing the anti-cancer natural product nimbolide for targeted protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/30788082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CSBJ.2019.01.006
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
PMC publication ID
6369262
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
PubMed publication ID
30788082
1 reference
stated in
Europe PubMed Central
PMC publication ID
6369262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30788082%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 April 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit