Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q40347061)
Watch
English
Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras.
scientific article published on 5 December 2016
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
title
Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
main subject
proteolysis
1 reference
based on heuristic
inferred from title
self-assembly
1 reference
based on heuristic
inferred from title
author
David J Wright
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
C N Johnson
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
author name string
Honorine Lebraud
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
Tom D Heightman
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
publication date
5 December 2016
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
published in
ACS Central Science
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
volume
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
issue
12
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
page(s)
927-934
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
cites work
In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Small-Molecule PROTACS: New Approaches to Protein Degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Protein degradation: Prime time for PROTACs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Catalytic in vivo protein knockdown by small-molecule PROTACs.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Targeting RAS-ERK signalling in cancer: promises and challenges
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Finding the right (bioorthogonal) chemistry.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
trans-Cyclooctene--a stable, voracious dienophile for bioorthogonal labeling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
ChromoHub: a data hub for navigators of chromatin-mediated signalling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Bioorthogonal imaging of aurora kinase A in live cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
ERK1/2 MAP kinases: structure, function, and regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Bioorthogonal small-molecule ligands for PARP1 imaging in living cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Impact of linker length on the activity of PROTACs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Identification of a primary target of thalidomide teratogenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Medicinal chemical properties of successful central nervous system drugs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Use of PROTACS as molecular probes of angiogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Chemical genetic control of protein levels: selective in vivo targeted degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
22 September 2017
A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
20 August 2018
Selective, rapid and optically switchable regulation of protein function in live mammalian cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5200928
retrieved
20 August 2018
Identifiers
DOI
10.1021/ACSCENTSCI.6B00280
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
PMC publication ID
5200928
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
PubMed publication ID
28058282
1 reference
stated in
Europe PubMed Central
PMC publication ID
5200928
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28058282%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 April 2020
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit