(Q64940546)

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12 April 2020

title

Delineating the role of cooperativity in the design of potent PROTACs for BTK (English)

1 reference

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12 April 2020

8

1 reference

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12 April 2020

Adelajda Zorba

1

1 reference

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Veerabahu Shanmugasundaram

12 April 2020

30

1 reference

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12 April 2020

author name string

Chuong Nguyen

2

1 reference

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12 April 2020

Yingrong Xu

3

1 reference

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12 April 2020

Jeremy Starr

4

1 reference

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12 April 2020

Kris Borzilleri

5

1 reference

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12 April 2020

James Smith

6

1 reference

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12 April 2020

Hongyao Zhu

7

1 reference

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12 April 2020

WeiDong Ding

9

1 reference

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12 April 2020

James Schiemer

10

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12 April 2020

Xidong Feng

11

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12 April 2020

Jeanne S Chang

12

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12 April 2020

Daniel P Uccello

13

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12 April 2020

Jennifer A Young

14

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12 April 2020

Carmen N Garcia-Irrizary

15

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12 April 2020

Lara Czabaniuk

16

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12 April 2020

Brandon Schuff

17

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12 April 2020

Robert Oliver

18

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12 April 2020

Justin Montgomery

19

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12 April 2020

Matthew M Hayward

20

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12 April 2020

Jotham Coe

21

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12 April 2020

Jinshan Chen

22

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12 April 2020

Mark Niosi

23

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12 April 2020

Suman Luthra

24

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12 April 2020

Jaymin C Shah

25

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12 April 2020

Ayman El-Kattan

26

1 reference

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12 April 2020

Xiayang Qiu

27

1 reference

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12 April 2020

Graham M West

28

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12 April 2020

Mark C Noe

29

1 reference

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12 April 2020

Adam M Gilbert

31

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12 April 2020

Matthew F Brown

32

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12 April 2020

Matthew F Calabrese

33

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12 April 2020

publication date

16 July 2018

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

12 April 2020

published in

1 reference

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12 April 2020

volume

115

1 reference

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12 April 2020

issue

31

1 reference

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12 April 2020

page(s)

E7285-E7292

1 reference

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Identification of the von Hippel-Lindau disease tumor suppressor gene

12 April 2020

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

BTK, the tyrosine kinase affected in X-linked agammaglobulinemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structural assembly of cullin-RING ubiquitin ligase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Development of target protein-selective degradation inducer for protein knockdown.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structure-based prediction of protein–protein interactions on a genome-wide scale

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A comprehensive mathematical model for three-body binding equilibria

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Building and remodelling Cullin-RING E3 ubiquitin ligases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Bruton's tyrosine kinase (BTK) inhibitors in clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Ibrutinib in B-cell Lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Oncogenic protein interfaces: small molecules, big challenges.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Catalytic in vivo protein knockdown by small-molecule PROTACs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Induced protein degradation: an emerging drug discovery paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Transcriptional Addiction in Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structural basis of PROTAC cooperative recognition for selective protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Identifiers

DOI

10.1073/PNAS.1803662115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30012605%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30012605%20AND%20SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

30012605

1 reference