(Q52585230)

http://europepmc.org/abstract/PMC/6294449

2 July 2019

title

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). (English)

1 reference

http://europepmc.org/abstract/PMC/6294449

2 July 2019

author

Katherine A Donovan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Radoslaw P Nowak

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Eric S. Fischer

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Chelsea E Powell

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Li Tan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Nathanael Gray

11

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10 June 2020

author name string

Yang Gao

2

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10 June 2020

Amanda Loehr

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Magda Bahcall

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Rani E George

10

1 reference

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10 June 2020

Pasi A Jänne

9

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10 June 2020

language of work or name

English

0 references

publication date

24 April 2018

1 reference

http://europepmc.org/abstract/PMC/6294449

2 July 2019

published in

Journal of Medicinal Chemistry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

61

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

4249-4255

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

10 June 2020

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

The anaplastic lymphoma kinase in the pathogenesis of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Identification of ALK as a major familial neuroblastoma predisposition gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Activating mutations in ALK provide a therapeutic target in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Anaplastic lymphoma kinase: signalling in development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Role of ERK-BIM and STAT3-survivin signaling pathways in ALK inhibitor-induced apoptosis in EML4-ALK-positive lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Comprehensive analysis of kinase inhibitor selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Anaplastic lymphoma kinase (ALK): structure, oncogenic activation, and pharmacological inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Discovery of a potent inhibitor of anaplastic lymphoma kinase with in vivo antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Drug resistance via feedback activation of Stat3 in oncogene-addicted cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Ceritinib: a new tyrosine kinase inhibitor for non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

limma powers differential expression analyses for RNA-sequencing and microarray studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

ABC transporters and neuroblastoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Expanding the portfolio of anti-ALK weapons

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

ALK inhibitors in non-small cell lung cancer: the latest evidence and developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

The Current Landscape of Anaplastic Lymphoma Kinase (ALK) in Non-Small Cell Lung Cancer: Emerging Treatment Paradigms and Future Directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29660984

12 December 2020

10.1021/ACS.JMEDCHEM.7B01655

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29660984%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

29660984

1 reference