(Q47411648)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Li Tan

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

19

Nathanael S Gray

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

15

Steven P Treon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

author name string

Hai-Tsang Huang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Dennis Dobrovolsky

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Joshiawa Paulk

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Guang Yang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ellen L Weisberg

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Zainab M Doctor

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Dennis L Buckley

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Joong-Heui Cho

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Eunhwa Ko

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Jaebong Jang

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Kun Shi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Hwan Geun Choi

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

James D Griffin

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

Ying Li

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

James E Bradner

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

publication date

9 November 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

published in

Cell Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

page(s)

88-99.e6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

2 April 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/6427047

inferred from PubMed Central ID database lookup

cites work

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Degradation of human Aurora-A protein kinase is mediated by hCdh1

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

FLT3 mutations in acute myeloid leukemia cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Identifying differentially expressed genes using false discovery rate controlling procedures

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

UniProt: the Universal Protein knowledgebase

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Functional interrogation of the kinome using nucleotide acyl phosphates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

A quantitative analysis of kinase inhibitor selectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Small molecules destabilize cIAP1 by activating auto-ubiquitylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Identification of a primary target of thalidomide teratogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Mechanisms of drug resistance in kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

In situ kinase profiling reveals functionally relevant properties of native kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

A comprehensive mathematical model for three-body binding equilibria

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Genome engineering using the CRISPR-Cas9 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Targeting Bruton's tyrosine kinase in B cell malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

The evolving role of FLT3 inhibitors in acute myeloid leukemia: quizartinib and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

limma powers differential expression analyses for RNA-sequencing and microarray studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

FDA-approved small-molecule kinase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Catalytic in vivo protein knockdown by small-molecule PROTACs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Protein degradation: Prime time for PROTACs

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Transcription control by the ENL YEATS domain in acute leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Structural basis of PROTAC cooperative recognition for selective protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29129717

12 December 2020

10.1016/J.CHEMBIOL.2017.10.005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29129717%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

PubMed publication ID

29129717

1 reference