(Q42217007)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29018234%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

title

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29018234%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

6

1 reference

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6 April 2020

Alessio Ciulli

9

1 reference

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6 April 2020

Chiara Maniaci

1

1 reference

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6 April 2020

Andrea Testa

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29018234%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

Dario Alessi

7

1 reference

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6 April 2020

Roberto Romeo

8

1 reference

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6 April 2020

author name string

Scott J Hughes

2

1 reference

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6 April 2020

Wenzhang Chen

4

1 reference

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6 April 2020

Douglas J Lamont

5

1 reference

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6 April 2020

language of work or name

English

0 references

publication date

10 October 2017

1 reference

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6 April 2020

published in

Nature Communications

1 reference

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6 April 2020

volume

8

1 reference

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6 April 2020

issue

1

1 reference

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6 April 2020

page(s)

830

1 reference

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Creative Commons Attribution 4.0 International

6 April 2020

copyright license

start time

10 October 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5635026/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.

26 October 2017

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A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

26 October 2017

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Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

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Drugging the undruggables: exploring the ubiquitin system for drug development

26 October 2017

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Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

26 October 2017

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Small-Molecule PROTACS: New Approaches to Protein Degradation

26 October 2017

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Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

26 October 2017

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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP

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Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein

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The promise and peril of chemical probes

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Catalytic in vivo protein knockdown by small-molecule PROTACs.

26 October 2017

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

26 October 2017

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

26 October 2017

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

26 October 2017

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DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

26 October 2017

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Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

26 October 2017

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26 October 2017

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VHL, the story of a tumour suppressor gene

26 October 2017

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26 October 2017

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Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

26 October 2017

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Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities

26 October 2017

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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

26 October 2017

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Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

26 October 2017

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The multifaceted von Hippel-Lindau tumour suppressor protein

26 October 2017

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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

26 October 2017

1 reference

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The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

26 October 2017

1 reference

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A comprehensive mathematical model for three-body binding equilibria

26 October 2017

1 reference

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Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

26 October 2017

1 reference

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26 October 2017

1 reference

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Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

26 October 2017

1 reference

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Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL.

26 October 2017

1 reference

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Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

26 October 2017

1 reference

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Identification of a primary target of thalidomide teratogenicity

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Targeting proteins for degradation

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

26 October 2017

1 reference

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Evidence for a stereoelectronic effect in human oxygen sensing.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Multitasking by pVHL in tumour suppression

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Mechanism of auxin perception by the TIR1 ubiquitin ligase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Drug discovery in the ubiquitin-proteasome system.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

The von Hippel-Lindau tumour suppressor: a multi-faceted inhibitor of tumourigenesis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Biochemical mechanisms of drug action: what does it take for success?

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

26 October 2017

1 reference

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Mechanisms underlying ubiquitination

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Controlling signal transduction with synthetic ligands

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Exact analysis of ligand-induced dimerization of monomeric receptors

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5635026

Types of Ubiquitin Ligases

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-00954-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41467-017-00954-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29018234%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

0 references

release_rprjo2ba6nby3l5pfviebmcu3y

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rprjo2ba6nby3l5pfviebmcu3y

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29018234%20AND%20SRC:MED&resulttype=core&format=json

6 April 2020

PubMed publication ID

29018234

1 reference