Nortriptilin

Nortriptilin
(IUPAC) ime
	3-(10,11-dihidro-5H-dibenzo[a,d] ciklohepten-5-iliden)- N-metil-1-propanamin
Klinički podaci
Robne marke	Aventil
AHFS/Drugs.com	Monografija
MedlinePlus	a682620
Identifikatori
CAS broj	72-69-5 ; 894-71-3 (hidrohlorid)
ATC kod	N06AA10
PubChem	4543
DrugBank	DB00540
ChemSpider	4384
UNII	BL03SY4LXB
KEGG	D08288
ChEBI	CHEBI:7640
ChEMBL	CHEMBL445
Hemijski podaci
Formula	C19H21N
Mol. masa	263,38 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 ; Key: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
Farmakokinetički podaci
Bioraspoloživost	Visoka
Metabolizam	Hepatički
Poluvreme eliminacije	16 - 90 sata
Izlučivanje	Renalno
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Oralno

Nortriptilin je lek iz druge generacije tricikličnih antidepresiva (TCA), koji se prodaje kao hidrohloridna so pod imenima Sensoval, Aventil, Pamelor, Norpres, Alegron, Noritren i Nortrilen. On se koristi u tretmanu kliničke depresije i dečje noćne enureze (mokrenja kreveta). Osim toga, on se ponekad koristi za hronične bolesti, kao što su sindrom hroničnog umora, hronični bol i migrena, i emocionalna labilnost u nekim neurološkim stanjima.

Klinička farmakologija

Nortriptilin je aktivni metabolit amitriptilina koi se demetiliše u jetri. On inhibira ponovno preuzimanje norepinefrina (noradrenalina), i u manjoj meri serotonina. On ima zanemarljiv efekat na preuzimanje dopamina. Nortriptilin takoše ima antagonistno dejstvo na mnoštvo receptora:

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Gillman PK (2007). „Tricyclic antidepressant pharmacology and therapeutic drug interactions updated”. Br J Pharmacol 151 (6): 737–48. DOI:10.1038/sj.bjp.0707253. PMC 2014120. PMID 17471183.

Povezano

Triciklični antidepresivi

Spoljašnje veze

	Portal Medicina
	Portal Hemija

Internet Mental Health Arhivirano 2006-04-27 na Wayback Machine-u - Nortriptyline
Drugs.com - Nortriptyline

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[Br_J_Pharmacol2007-Gillman-6] Gillman PK (2007). „Tricyclic antidepressant pharmacology and therapeutic drug interactions updated”. Br J Pharmacol 151 (6): 737–48. DOI:10.1038/sj.bjp.0707253. PMC 2014120. PMID 17471183.

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