AL-38022A

AL-38022A
(IUPAC) ime
	(S)-2-(8,9-dihidro-7H-pirano[2,3-g]indazol-1-il)-1-metiletilamin
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	22496603
Hemijski podaci
Formula	C13H17N3O
Mol. masa	231.293 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H17N3O/c1-9(14)8-16-13-10(7-15-16)4-5-12-11(13)3-2-6-17-12/h4-5,7,9H,2-3,6,8,14H2,1H3/t9-/m0/s1 ; Key: FJRIVFVALIEIOY-UHFFFAOYSA-N
Fizički podaci
Tačka topljenja	106–107 °C (223–225 °F)
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

AL-38022A je derivat indazola. Ovaj lek pripada nizu sličnih lekova koji su razvijeni za potrebe naučnih istraživanja. Neki od njih imaju potencijalnu kliničku primenu. AL-38022A je potentan i selektivan agonist 5-HT₂ familije serotoninskih receptora, sa najvišim afinitetom vezivanja za 5-HT_2C tip receptora i oko 4x manjim afinitetom za 5-HT_2A i 5-HT_2B. U životinjskim studijama on potpuno zamenjuje DOM i 5-MeO-DMT.^[3]

Povezano

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ May, JA; Sharif, NA; Chen, HH; Liao, JC; Kelly, CR; Glennon, RA; Young, R; Li, JX i dr.. (2009). „Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A (S)-2-(8,9-dihydro-7H-pyrano2,3-gindazol-1-yl)-1-methylethylamine”. Pharmacology, biochemistry, and behavior 91 (3): 307–14. DOI:10.1016/j.pbb.2008.07.015. PMID 18718483.

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] May, JA; Sharif, NA; Chen, HH; Liao, JC; Kelly, CR; Glennon, RA; Young, R; Li, JX i dr.. (2009). „Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A (S)-2-(8,9-dihydro-7H-pyrano2,3-gindazol-1-yl)-1-methylethylamine”. Pharmacology, biochemistry, and behavior 91 (3): 307–14. DOI:10.1016/j.pbb.2008.07.015. PMID 18718483.

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