25I-NBOH

25I-NBOH
(IUPAC) ime
	2-((2-(4-jodo-2,5-dimetoksifenil)etilamino)metil)fenol
Klinički podaci
Identifikatori
CAS broj	919797-20-9
ATC kod	nije dodeljen
PubChem	10001761
ChemSpider	8177342
Hemijski podaci
Formula	C17H20INO3
Mol. masa	413,249 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H20INO3/c1-21-16-10-14(18)17(22-2)9-12(16)7-8-19-11-13-5-3-4-6-15(13)20/h3-6,9-10,19-20H,7-8,11H2,1-2H3 ; Key: FEUZHYRXGQTBRO-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

25I-NBOH (NBOH-2CI, Cimbi-27) je fenetilaminski halucinogen. On deluje kao potentan agonist 5HT_2A receptora,^[4]^[5] sa Ki od 0,061 nM na ljudskom 5HT_2A receptoru, te je dvanaest puta potentniji od liganda 2C-I. In vitro testovi su pokazali da ovo jedinjenje deluje kao agonist, ali rezultati životinjskih studija nisu objavljeni. Dok su N-benzilni derivati 2C-I liganda znatno povećavali potentnost, N-benzil derivati 2,5-dimetoksi-4-jodoamfetamina su neaktivni.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Ettrup, A. et al. (2010). „Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers”. European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. DOI:10.1007/s00259-010-1686-8. ISBN 0025901016868. PMID 21174090.
↑ Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design 25 (1): 51–66. DOI:10.1007/s10822-010-9400-2. PMID 21088982.
↑ Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE (2006). „Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists”. Molecular Pharmacology 70 (6): 1956–64. DOI:10.1124/mol.106.028720. PMID 17000863.

Povezano

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Ettrup, A. et al. (2010). „Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers”. European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693. DOI:10.1007/s00259-010-1686-8. ISBN 0025901016868. PMID 21174090.

[pmid21088982-5] Silva ME, Heim R, Strasser A, Elz S, Dove S (January 2011). „Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor”. Journal of Computer-aided Molecular Design 25 (1): 51–66. DOI:10.1007/s10822-010-9400-2. PMID 21088982.

[6] Braden, MR; Parrish, JC; Naylor, JC; Nichols, DE (2006). „Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists”. Molecular Pharmacology 70 (6): 1956–64. DOI:10.1124/mol.106.028720. PMID 17000863.

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