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Targeted protein degradation: elements of PROTAC design
scientific article published on 17 April 2019
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Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
title
Targeted protein degradation: elements of PROTAC design
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
author
Stacey-Lynn Paiva
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
author name string
Craig M Crews
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
publication date
17 April 2019
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
published in
Current Opinion in Chemical Biology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
volume
50
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
page(s)
111-119
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
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12 December 2020
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Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
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12 December 2020
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Building better vasculature
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12 December 2020
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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
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12 December 2020
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12 December 2020
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12 December 2020
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12 December 2020
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Physiological functions of the HECT family of ubiquitin ligases
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12 December 2020
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RING domain E3 ubiquitin ligases
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12 December 2020
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Building ubiquitin chains: E2 enzymes at work
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12 December 2020
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Selective inhibition of BET bromodomains
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12 December 2020
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The N-end rule pathway and regulation by proteolysis
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
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RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
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12 December 2020
based on heuristic
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Bromodomains as therapeutic targets
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
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HECT and RING finger families of E3 ubiquitin ligases at a glance
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
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Epigenetic protein families: a new frontier for drug discovery
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PubMed
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12 December 2020
based on heuristic
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The ubiquitin code
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
BET domain co-regulators in obesity, inflammation and cancer
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
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Targeting epigenetic readers in cancer.
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
RING-between-RINGs--keeping the safety on loaded guns
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
1 reference
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PubMed
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface
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12 December 2020
based on heuristic
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Kinase drug discovery--what's next in the field?
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cancer drug resistance: an evolving paradigm
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12 December 2020
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New insights into ubiquitin E3 ligase mechanism
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PubMed
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
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12 December 2020
based on heuristic
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Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities
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PubMed
reference URL
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Catalytic in vivo protein knockdown by small-molecule PROTACs.
1 reference
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells
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12 December 2020
based on heuristic
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SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.
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12 December 2020
based on heuristic
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Transcription control by the ENL YEATS domain in acute leukaemia
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12 December 2020
based on heuristic
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Structural basis of PROTAC cooperative recognition for selective protein degradation
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12 December 2020
based on heuristic
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Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
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Ubiquitin Ligases: Structure, Function, and Regulation.
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).
1 reference
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.
1 reference
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.
1 reference
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https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted protein knockdown using small molecule degraders
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Drug-Target Kinetics in Drug Discovery.
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small-Molecule Modulation of Protein Homeostasis.
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
RING-Between-RING E3 Ligases: Emerging Themes amid the Variations.
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MELK is not necessary for the proliferation of basal-like breast cancer cells
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a peptide-based inducer of protein degradation targeting NOTCH1.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling.
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The target landscape of clinical kinase drugs
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https://pubmed.ncbi.nlm.nih.gov/31004963
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α.
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The dTAG system for immediate and target-specific protein degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK).
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase using PROTAC-mediated Degradation.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of the first small molecule histone deacetylase 6 (HDAC6) degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted protein degradation and the enzymology of degraders
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Plasticity in binding confers selectivity in ligand-induced protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Delineating the role of cooperativity in the design of potent PROTACs for BTK.
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Homo-PROTACs for the Chemical Knockdown of Cereblon
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin-proteasome pathway
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A novel class of viral Ankyrin proteins targeting the host E3 ubiquitin ligase Cullin-2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Targeted Degradation of MDM2 as a New Approach to Improve the Efficacy of MDM2-p53 Inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
N-degron and C-degron pathways of protein degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
PROTAC-mediated crosstalk between E3 ligases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/31004963
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CBPA.2019.02.022
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
PubMed publication ID
31004963
1 reference
stated in
Europe PubMed Central
PubMed publication ID
31004963
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31004963%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 April 2020
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