(Q64269515)

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21 April 2020

title

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate (English)

1 reference

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21 April 2020

8

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21 April 2020

author name string

Sandra Winkler

2

1 reference

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21 April 2020

Claire Whitworth

4

1 reference

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21 April 2020

Michael Galant

5

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21 April 2020

William Farnaby

6

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21 April 2020

Klaus Rumpel

7

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21 April 2020

Michael J Roy

1

1 reference

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21 April 2020

Scott J Hughes

3

1 reference

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21 April 2020

publication date

22 February 2019

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21 April 2020

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21 April 2020

volume

14

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21 April 2020

issue

3

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21 April 2020

page(s)

361-368

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A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation

21 April 2020

cites work

1 reference

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12 December 2020

Quantifying the energetics of cooperativity in a ternary protein complex.

1 reference

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12 December 2020

Characterization of the FKBP.rapamycin.FRB ternary complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Analyzing a kinetic titration series using affinity biosensors

1 reference

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12 December 2020

Drug-target residence time and its implications for lead optimization

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12 December 2020

Azurin modulates the association of Mdm2 with p53: SPR evidence from interaction of the full-length proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Single-cycle kinetic analysis of ternary DNA complexes by surface plasmon resonance on a decaying surface.

1 reference

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12 December 2020

A comprehensive mathematical model for three-body binding equilibria

1 reference

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12 December 2020

Site-specific biotinylation of purified proteins using BirA.

1 reference

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12 December 2020

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

The drug-target residence time model: a 10-year retrospective

1 reference

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12 December 2020

Targeted Protein Degradation by Small Molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Structural basis of PROTAC cooperative recognition for selective protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Targeted protein knockdown using small molecule degraders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Small Molecule Targeted Recruitment of a Nuclease to RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Targeted protein degradation and the enzymology of degraders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Plasticity in binding confers selectivity in ligand-induced protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Delineating the role of cooperativity in the design of potent PROTACs for BTK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Dynamic Imaging of Small Molecule Induced Protein-Protein Interactions in Living Cells with a Fluorophore Phase Transition Based Approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

1 reference

https://pubmed.ncbi.nlm.nih.gov/30721025

12 December 2020

10.1021/ACSCHEMBIO.9B00092

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30721025%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

1 reference

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21 April 2020

PubMed publication ID

30721025

1 reference