ICP may refer to:
Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. It is produced by herpes viruses during the earliest stage of infection, when the virus has recently entered the host cell; this stage is known as the immediate-early or α ("alpha") phase of viral gene expression. During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. Here, ICP0 promotes transcription from viral genes, disrupts structures in the nucleus known as nuclear dots or promyelocytic leukemia (PML) nuclear bodies, and alters the expression of host and viral genes in combination with a neuron specific protein. At later stages of cellular infection, ICP0 relocates to the cell cytoplasm to be incorporated into new virion particles.
ICP0 was identified as an immediate-early polypeptide product of Herpes simplex virus-1 (HSV-1) infection in 1976. The gene, in HSV-1, from which ICP0 is produced is known as HSV-1 α0 ("alpha zero"), Immediate Early (IE) gene 1, or simply as the HSV-1 ICP0 gene. The HSV-1 ICP0 gene was characterized and sequenced in 1986. This sequence predicted a 775 amino acid sequence with a molecular weight of 78.5 KDa. At the time of gene isolation, ICP0 was known as IE110 as gel electrophoresis experiments performed prior to obtaining the gene sequence indicated the ICP0 protein weighed 110 kDa. Post-translational modifications, such as phosphorylation or sumoylation, were presumed to account for the actual protein size appearing 30 kDa larger than that of the predicted amino acid sequence.
ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of dsDNA; its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent. In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.
ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.
Jump out of bed and I head for the grapenuts
Eat 'em quick or they soggy and that sucks
Trying to find a clean pair of socks and a shirt
Still sporting the same drawers even though they hurt
In the fridge, there's a Faygo, it tastes ill
Cuz it's flatter then a bitch on a big wheel
I got a few money back and a little change
So I'm heading to the store when the phone rings
"What up man, check it out, I know this bitch
She's got another friend with her and her dad's rich
If we find us a ride out to Wyandotte
Guaranteed, we can fuck 'em both on the spot"
Oh shit, let me call Bill Bill
I wanna go and let my nuts do the windmill
He ain't home, fuck, I'll call Mike Clark
Cuz I know he can get the fuckin Skylark
He said he can, but he's broke and it needs gas
But I wanna buy these Faygo, think fast
I know my brother Jump Steady's got a few bones
But that's going through his shit when he ain't home
"Nevermind J, Legs loned me a ten
No need to get punched in your head again
Tell Mike to scoop me up right away
And it's Faygo and neden hoes all day"
Fuck yeah, I throw my Pro Winds on my feet
Lock the house, and wait for 'em in the street
I wish I had a piece of gum or something fuck
My mouth still kind of tastes grapenuts
Here they come, nope, wasn't them
Seems like the same car's driving by again
It pulls up, "hey man, you're outta luck"
What, what ya say man