ICP
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HHV Infected Cell Polypeptide 0
Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. It is produced by herpes viruses during the earliest stage of infection, when the virus has recently entered the host cell; this stage is known as the immediate-early or α ("alpha") phase of viral gene expression. During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. Here, ICP0 promotes transcription from viral genes, disrupts structures in the nucleus known as nuclear dots or promyelocytic leukemia (PML) nuclear bodies, and alters the expression of host and viral genes in combination with a neuron specific protein. At later stages of cellular infection, ICP0 relocates to the cell cytoplasm to be incorporated into new virion particles.
History and background
ICP0 was identified as an immediate-early polypeptide product of Herpes simplex virus-1 (HSV-1) infection in 1976. The gene, in HSV-1, from which ICP0 is produced is known as HSV-1 α0 ("alpha zero"), Immediate Early (IE) gene 1, or simply as the HSV-1 ICP0 gene. The HSV-1 ICP0 gene was characterized and sequenced in 1986. This sequence predicted a 775 amino acid sequence with a molecular weight of 78.5 KDa. At the time of gene isolation, ICP0 was known as IE110 as gel electrophoresis experiments performed prior to obtaining the gene sequence indicated the ICP0 protein weighed 110 kDa. Post-translational modifications, such as phosphorylation or sumoylation, were presumed to account for the actual protein size appearing 30 kDa larger than that of the predicted amino acid sequence.
ICP8
ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of dsDNA; its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent. In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.
ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.
See also
References
External links
Podcasts:
I.C.P.
ALBUMS
- Free & Equal released: 1992
Insane Clown Posse
ALBUMS
- 20th Anniversary Hallowicked Collection released: 2014
- Forgotten Freshness, Volume 5 released: 2013
- Freaky Tales released: 2012
- Smothered, Covered & Chunked released: 2012
- Mike E. Clark's Extra Pop Emporium released: 2012
- Best of Insane Clown Posse released: 2012
- The Mighty Death Pop! released: 2012
- Featuring Freshness released: 2011
- Bang! Pow! Boom! released: 2010
- Playlist Your Way released: 2008
- Jugganauts: The Best of ICP released: 2007
- The Tempest released: 2007
- The Wraith: Remix Albums released: 2006
- Forgotten Freshness, Volume 4 released: 2005
- The Wraith: Hell's Pit released: 2004
- The Pendulum released: 2002
- Forgotten Freshness, Volume 3 released: 2001
- Bizaar released: 2000
- The Amazing Jeckel Brothers released: 1999
- Carnival of Carnage released: 1998
- Ringmaster released: 1998
- Forgotten Freshness, Volumes 1 & 2 released: 1998
- The Great Milenko released: 1997
- Mutilation Mix released: 1996
- Forgotten Freshness released: 1995
- Riddle Box released: 1995
- The Tempest: DJ Mix Kit released:
- The Complete Pendulum released:
- 1999-07-23: Woodstock '99, Rome, NY, USA released:
- The Pendulum released:
- Instrumentals, Volume 1 released:
- Big Money Hustlas released:
- The Wraith: Shangri-La released:
Forgotten Freshness, Volume 5
Released 2013- Intro
- Right Now
- Duke of the Wicked
- Jacob's Word
- Mind of Howard Stern
- Raise From the Ground!
- The Great Show (original version)
- Rare Milenko Phone Skit
- The Kreayshawn Song
- Goblin
- Fuck My Dad (Richard Bruce)
- Get Geeked
- Someone's Gonna Die
- I'm an Alien
- The 1st Gathering
- I Can't Wait
- Mancow Made Us
- Mountain Girl
- It's Going Down
- Party in the Woods
Mike E. Clark's Extra Pop Emporium
Released 2012- Traveling Circus
- Chris Benoit (Kuma's Scrub club remix)
- When I'm Clownin' (Kuma's Clownin' remix)
- Lost in the Music
- Up Ya Ass (outtake)
- Ghetto Rainbows (Soft Ass R-N-B remix)
- Birfday Party (outtake)
- Scrubstitute Teachers
- Playin' in the Woods (outtake)
- Pass It to the Sky
- Shugston Brooks 1959-2004 (outtake)
- Night of the Chainsaw (Joe Strange remix)
- Forever (extended Geto mix)
- Untitled (outtakes)
Featuring Freshness
Released 2011- Lady in a Jaguar (feat. Insane Clown Posse)
- Put It Down (feat. Insane Clown Posse)
- Keep It Wicked (feat. Insane Clown Posse)
- The Party (feat. DJ Clay)
- Marsh Lagoon (feat. Insane Clown Posse)
- Gang Related (feat. Insane Clown Posse)
- The Gathering (feat. Insane Clown Posse)
- Birthday (feat. Insane Clown Posse)
- This Bitch (feat. Insane Clown Posse)
- Always Fucking With Us (feat. Insane Clown Posse)
- Whoop (feat. Insane Clown Posse & Axe Murder Boyz)
- I Don't Care (feat. Twiztid)
- Nightline (feat. Insane Clown Posse)
- Hound Dogs (feat. Blaze & Insane Clown Posse)
- Kept Grindin' (feat. Insane Clown Posse, Twiztid, Blaze, Boondox, Axe Murder Boyz & ABK)
Jugganauts: The Best of ICP
Released 2007- Great Milenko
- Hokus Pokus
- Piggy Pie (Old School)
- The Neden Game
- Halls of Illusions
- Mad Professor
- Boogie Woogie Wu
- Cherry Pie (I Need a Freak)
- Another Love Song
- Rainbows & Stuff
- I Want My Shit
- Fuck the World
- Bitches (feat. Ol' Dirty Bastard)
- My Axe
- Tilt-A-Whirl
- Please Don't Hate Me
- Let's Go All the Way
- What Is a Juggalo?
The Wraith: Remix Albums
Released 2006- Walk Into the Light (Mike E. Clark remix)
- Welcome to Thy Show (Kuma remix)
- Get Ya Wicked On (Wolfpac remix)
- Murder Rap (Filthee Immigrants remix)
- Birthday Bitches (Kuma remix)
- Blaaam!!! (Tino Gross remix)
- It Rains Diamonds/Bitch Slappaz (Kuma Remixes)
- Thy Staleness (Fritz the Cat remix)
- Hell's Forecast (Mike E. Clark remix)
- Juggalo Homies (Mike E. Clark remix)
- We Belong (Kottonmouth Kings remix)
- Cotton Candy & Popsicles (Filthee Immigrants remix)
- Crossing Thy Bridge (Kuma remix)
- Thy Raven's Mirror (Fritz the Cat remix)
- Thy Wraith (Tino Gross remix)
Forgotten Freshness, Volume 4
Released 2005- Intro
- The People
- Clown Walk
- If I Was King
- Dear Icp
- Madhouse (feat. Tech N9ne)
- Feels So Right
- Homies (feat. Twiztid) (Mike E. Clark mix)
- Staaaaaaaaale!!!
- Bodies Fly
- Wicked Rappers Delight (feat. Esham)
- Panties
- If You Can't Beat 'Em, Join 'Em
- Nobody Move (feat. Mack 10)
- Yours Begins Tonight
- C.P.K.'s (Mike E. Clark mix)
- Swallow This Nut (feat. Fresh Kid Ice, Fish n Grits, MC Breed & Vanilla Ice)
Mutilation Mix
Released 1996- Request #1
- Cemetery Girl
- Hey Vato
- Wagon Wagon
- Request #2
- Psychopathic
- Southwest Strangla
- Never Had It Made
- Chicken Huntin' (Slaughterhouse mix)
- I Stuck Her With My Wang
- The Loons
- Red Neck Hoe
- Request #3
- I'm Comin' Home
- Super Balls
- The Stalker
- Wizard of the Hood
- Skitsofrantic
- 3 Rings
- Request #4
- Murder Go 'Round
- Request #5
- Southwest Song
- Fuck Off!
- The Dead Body Man
- Cotton Candy
- 17 Dead
- Request #6
- The Neden Game
- House of Wonders + Mike Clark Bxtchin'
The Tempest: DJ Mix Kit
- Haunted Bumps (album version)
- I Do This! (album version)
- The Party (album version)
- Haunted Bumps (Polar Bear remix)
- I Do This! (Polar Bear remix)
- The Party (Mike E. Clark remix)
- Haunted Bumps (Akuna remix)
- I Do This! (Akuna remix)
- The Party (Akuna remix)
- Haunted Bumps (album version instrumental)
- I Do This! (album version instrumental)
- The Party (album version instrumental)
- Haunted Bumps (a cappella version)
- I Do This! (a cappella version)
- The Party (a cappella version)
- Haunted Bumps (album version clean edit)
- I Do This! (album version clean edit)
- The Party (album version clean edit)
ICP
ALBUMS
- Y'Anbessaw Tezeta released: 2012
- Repentance released: 2003
ICP Orchestra
ALBUMS
- Live at the Bimhuis released: 2009
- Jubilee Varia released: 1999
- Bospaadje Konijnehol I released:
- Oh, My Dog! released:
Bospaadje Konijnehol I
- Bospaadje Konijnehol 1
- Ellington Mix: Mooche Mix
- Ellington Mix: Moodmixes Indigo
- Ellington Mix: Mixed Caravan
- Ellington Mix: Happy Go Lucky Local Mix
- Ellington Mix: Mix Solitude
- Ellington Mix: It Don't Mix
- De Purperen Sofa: Zitten en Liggen
- De Purperen Sofa: De Poezenkant
- De Purperen Sofa: Het Kraken
- De Purperen Sofa: Vondsten in het Binnenwerk
- De Purperen Sofa: Een Gewelfde Rugleuning
- De Purperen Sofa: Kale Plekken
Alternative Video Results
- Which Altcoins Will Continue to Rally?! (ICP, AAVE)
- ICP Crypto is Officially Deflationary (What it Means)
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Just Like That
by: I.C.P.Jump out of bed and I head for the grapenuts
Eat 'em quick or they soggy and that sucks
Trying to find a clean pair of socks and a shirt
Still sporting the same drawers even though they hurt
In the fridge, there's a Faygo, it tastes ill
Cuz it's flatter then a bitch on a big wheel
I got a few money back and a little change
So I'm heading to the store when the phone rings
"What up man, check it out, I know this bitch
She's got another friend with her and her dad's rich
If we find us a ride out to Wyandotte
Guaranteed, we can fuck 'em both on the spot"
Oh shit, let me call Bill Bill
I wanna go and let my nuts do the windmill
He ain't home, fuck, I'll call Mike Clark
Cuz I know he can get the fuckin Skylark
He said he can, but he's broke and it needs gas
But I wanna buy these Faygo, think fast
I know my brother Jump Steady's got a few bones
But that's going through his shit when he ain't home
"Nevermind J, Legs loned me a ten
No need to get punched in your head again
Tell Mike to scoop me up right away
And it's Faygo and neden hoes all day"
Fuck yeah, I throw my Pro Winds on my feet
Lock the house, and wait for 'em in the street
I wish I had a piece of gum or something fuck
My mouth still kind of tastes grapenuts
Here they come, nope, wasn't them
Seems like the same car's driving by again
It pulls up, "hey man, you're outta luck"
What, what ya say man
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