ICP srl

ICP srl is an Italian wiring harness, automotive brake wear indicator and aircraft manufacturer founded by Tancredi (Edi) Razzano in 1980 and originally based in Piovà Massaia. The company relocated to Castelnuovo Don Bosco in Piedmont on 10 September 2009. ICP specializes in the design and manufacture of kit aircraft for amateur construction.

History

ICP was founded in 1980 to produce wiring harnesses for the automotive, electromechanical and domestic appliance markets. In 1984 the company expanded into designing and producing wear indicators for disc and drum brakes for cars, industrial vehicles and motorcycles. The company provides wear indicators that are used by Alfa Romeo, Audi, Citroen, Chevrolet Corvette, Daf, Ferrari, Fiat, Iveco, Lamborghini, Lancia, Maserati, Peugeot, Renault and Volvo.

In the late 1990s Razzano decided to use the considerable investment he had made in CNC machining to produce kit aircraft, beginning with the ICP Bingo and Savannah aircraft. The use of the CNC machines allowed kits to be produced at low cost, making the company very competitive in the kit aircraft market.Zenith STOL CH 701 designer Chris Heintz considers the Savannah an unauthorized copy of his design.

ICP

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HHV Infected Cell Polypeptide 0

Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. It is produced by herpes viruses during the earliest stage of infection, when the virus has recently entered the host cell; this stage is known as the immediate-early or α ("alpha") phase of viral gene expression. During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. Here, ICP0 promotes transcription from viral genes, disrupts structures in the nucleus known as nuclear dots or promyelocytic leukemia (PML) nuclear bodies, and alters the expression of host and viral genes in combination with a neuron specific protein. At later stages of cellular infection, ICP0 relocates to the cell cytoplasm to be incorporated into new virion particles.

History and background

ICP0 was identified as an immediate-early polypeptide product of Herpes simplex virus-1 (HSV-1) infection in 1976. The gene, in HSV-1, from which ICP0 is produced is known as HSV-1 α0 ("alpha zero"), Immediate Early (IE) gene 1, or simply as the HSV-1 ICP0 gene. The HSV-1 ICP0 gene was characterized and sequenced in 1986. This sequence predicted a 775 amino acid sequence with a molecular weight of 78.5 KDa. At the time of gene isolation, ICP0 was known as IE110 as gel electrophoresis experiments performed prior to obtaining the gene sequence indicated the ICP0 protein weighed 110 kDa. Post-translational modifications, such as phosphorylation or sumoylation, were presumed to account for the actual protein size appearing 30 kDa larger than that of the predicted amino acid sequence.

ICP8

ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication. It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of dsDNA; its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg²⁺-independent. In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.

ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.

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SRL

SRL or S.R.L. may refer to

Sarcalumenin

Sarcalumenin is a protein that in humans is encoded by the SAR gene.

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle. Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins. Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.

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