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Functional Biomaterials for Regenerative Dentistry
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Functional Biomaterials for Regenerative Dentistry

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 6158

Special Issue Editor

Dr. Nicholas G. Fischer

E-Mail Website
Guest Editor
Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN, USA
Interests: extracellular matrix signaling; dental biomaterials; surface modification; antimicrobial biomaterials; hemidesmosomes; surface analysis; peptide-based biomaterials

Special Issue Information

Dear Colleagues,

Regenerative dentistry aims to replace diseased and damaged tissue with functionally integrated regenerated tissue rather than conventional bonded or embedded synthetic materials. The wide array of oral tissues that require regeneration due to common diseases—the periodontal ligament supporting sound biomechanical integration of teeth, the dental pulp maintaining tooth vitality, the alveolar bone supporting function of overlying tissue and retention of teeth, and mineralized tooth structure—presents many daunting challenges. Overcoming these challenges is essential for oral health and the associated benefits to the well-being and lifestyle of patients. 

Biomaterials that promote regeneration serve a growing role in the dentist’s repertoire of tools and techniques. The inherent patient-specific, adaptable, biocompatible, and immunomodulatory nature of regenerative biomaterials positions them as the future of everyday dental practice. The long history of dentistry’s surgical techniques, combined with the wide scope of biomaterials being developed for nearly every diseased human tissue, produces an exciting opportunity for the development of functional regenerative biomaterials in dentistry. The objective of this Special Issue is to publish the latest research on the development of functional biomaterials for regenerative dentistry—broadly defined—to highlight the present and future capacity of dentistry to lead the way in tissue regeneration.

Dr. Nicholas G. Fischer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental implant
  • scaffold
  • hydrogel
  • bone regeneration
  • antimicrobial
  • bioactive material
  • biocompatibility
  • surface
  • immunomodulation
  • extracellular matrix

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Published Papers (4 papers)

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Research

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11 pages, 1657 KiB  
Article
Osteoinductive Properties of Autologous Dentin: An Ex Vivo Study on Extracted Teeth
by Giulia Mazzucchi, Alessia Mariano, Giorgio Serafini, Luca Lamazza, Anna Scotto d’Abusco, Alberto De Biase and Marco Lollobrigida
J. Funct. Biomater. 2024, 15(6), 162; https://doi.org/10.3390/jfb15060162 - 12 Jun 2024
Cited by 1 | Viewed by 999
Abstract
Over the last decades, a variety of biomaterials, ranging from synthetic products to autologous and heterologous grafts, have been recommended to conserve and regenerate bone tissue after tooth extraction. We conducted a biochemical study on ground extracted teeth that aimed to evaluate the [...] Read more.
Over the last decades, a variety of biomaterials, ranging from synthetic products to autologous and heterologous grafts, have been recommended to conserve and regenerate bone tissue after tooth extraction. We conducted a biochemical study on ground extracted teeth that aimed to evaluate the osteoinductive and osteoconductive potential of dentin by assessing the releases of bone morphogenetic protein (BMP-2), osteocalcin (OC) and osteonectin (ON) over time (24 h, 10 days and 28 days). Twenty-six patients, who required the extraction of nonrestorable teeth, were enrolled in the study according to the inclusion criteria, as follows: thirteen young patients 18 to 49 years of age (UNDER 50), and thirteen patients of 50 to 70 years (OVER 50); a total of twenty-six teeth were extracted, ground and analyzed by enzyme-linked immunosorbent assays (ELISA). All ground teeth released BMP-2, OC and ON at each time point; no differences were observed between the UNDER-50 and OVER-50 patients. The results of the study support the use of autologous dentin as osteoinductive material for bone regeneration procedures, irrespective of patients’ ages. Full article
(This article belongs to the Special Issue Functional Biomaterials for Regenerative Dentistry)
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16 pages, 6751 KiB  
Article
In Vitro Effects of Weissella cibaria CMU and CMS1 on Receptor Activator of NF-κB Ligand (RANKL)-Induced Osteoclast Differentiation
by Geun-Yeong Park, Jeong-Ae Park and Mi-Sun Kang
J. Funct. Biomater. 2024, 15(3), 65; https://doi.org/10.3390/jfb15030065 - 8 Mar 2024
Viewed by 1470
Abstract
Excessive osteoclast activity can promote periodontitis-associated bone destruction. The inhibitory mechanisms of Weissella cibaria strains CMU and CMS1 against periodontitis have not yet been fully elucidated. In this study, we aimed to investigate whether heat-killed (HK) W. cibaria CMU and CMS1 or their [...] Read more.
Excessive osteoclast activity can promote periodontitis-associated bone destruction. The inhibitory mechanisms of Weissella cibaria strains CMU and CMS1 against periodontitis have not yet been fully elucidated. In this study, we aimed to investigate whether heat-killed (HK) W. cibaria CMU and CMS1 or their respective cell-free supernatants (CFSs) inhibit osteoclast differentiation and bone resorption in response to receptor activator of nuclear factor kappa-B ligand (RANKL)-treated RAW 264.7 cells. TRAP (tartrate-resistant acid phosphatase) staining and bone resorption assays revealed that both HK bacteria and CFSs significantly suppressed the number of TRAP-positive cells, TRAP activity, and bone pit formation compared to the RANKL-treated control (p < 0.05). HK bacteria dose-dependently inhibited osteoclastogenesis while selectively regulating certain genes in CFSs (p < 0.05). We found that disrupting the direct interaction between HK bacteria and RAW 264.7 cells abolished the inhibitory effect of HK bacteria on the expression of osteoclastogenesis-associated proteins (c-Fos, nuclear factor of activated T cells c1 (NFATc1), and cathepsin K). These results suggest that dead bacteria suppress osteoclast differentiation more effectively than the metabolites and may serve as beneficial agents in preventing periodontitis by inhibiting osteoclast differentiation via direct interaction with cells. Full article
(This article belongs to the Special Issue Functional Biomaterials for Regenerative Dentistry)
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13 pages, 3614 KiB  
Article
Reconstructive Approach in Residual Periodontal Pockets with Biofunctionalized Heterografts—A Retrospective Comparison of 12-Month Data from Three Centers
by Anton Friedmann, Pheline Liedloff, Meizi Eliezer, Arthur Brincat, Thomas Ostermann and Daniel Diehl
J. Funct. Biomater. 2024, 15(2), 39; https://doi.org/10.3390/jfb15020039 - 9 Feb 2024
Viewed by 1693
Abstract
The regenerative capacity of well-preserved blood clots may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) treated intrabony defects combining cross-linked high-molecular-weight hyaluronic acid (xHyA) with a [...] Read more.
The regenerative capacity of well-preserved blood clots may be enhanced by biologics like enamel matrix derivative (EMD). This retrospective analysis compares outcomes reported by three centers using different heterografts. Center 1 (C1) treated intrabony defects combining cross-linked high-molecular-weight hyaluronic acid (xHyA) with a xenograft; center 2 (C2) used EMD with an allograft combination to graft a residual pocket. Center 3 (C3) combined xHyA with the placement of a resorbable polymer membrane for defect cover. Clinical parameters, BoP reduction, and radiographically observed defect fill at 12-month examination are reported. The 12-month evaluation yielded significant improvements in PPD and CAL at each center (p < 0.001, respectively). Analyses of Covariance revealed significant improvements in all parameters, and a significantly greater CAL gain was revealed for C2 vs. C1 (p = 0.006). Radiographic defect fill presented significantly higher scores for C2 and C3 vs. C1 (p = 0.003 and = 0.014; C2 vs. C3 p = 1.00). Gingival recession increased in C1 and C3 (p = 1.00), while C2 reported no GR after 12 months (C2:C1 p = 0.002; C2:C3 p = 0.005). BoP tendency and pocket closure rate shared similar rates. Within the limitations of the study, a data comparison indicated that xHyA showed a similar capacity to enhance the regenerative response, as known for EMD. Radiographic follow-up underlined xHyA’s unique role in new attachment formation. Full article
(This article belongs to the Special Issue Functional Biomaterials for Regenerative Dentistry)
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Review

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24 pages, 1663 KiB  
Review
The Integration of Gold Nanoparticles into Dental Biomaterials as a Novel Approach for Clinical Advancement: A Narrative Review
by Saharat Jongrungsomran, Dakrong Pissuwan, Apichai Yavirach, Chaiy Rungsiyakull and Pimduen Rungsiyakull
J. Funct. Biomater. 2024, 15(10), 291; https://doi.org/10.3390/jfb15100291 - 30 Sep 2024
Viewed by 1312
Abstract
Gold nanoparticles (AuNPs) have gained significant attention in the biomedical field owing to their versatile properties. AuNPs can be customized by modifying their size, shape and surface characteristics. In recent years, extensive research has explored the integration of AuNPs into various dental materials, [...] Read more.
Gold nanoparticles (AuNPs) have gained significant attention in the biomedical field owing to their versatile properties. AuNPs can be customized by modifying their size, shape and surface characteristics. In recent years, extensive research has explored the integration of AuNPs into various dental materials, including titanium, polymethylmethacrylate (PMMA) and resin composites. This review aims to summarize the advancements in the application of modified AuNPs in dental materials and to assess their effects on related cellular processes in the dental field. Relevant articles published in English on AuNPs in association with dental materials were identified through a systematic search of the PubMed/MEDLINE, Embase, Scopus and ScienceDirect databases from January 2014 to April 2024. Future prospects for the utilization of AuNPs in the field of dentistry are surveyed. Full article
(This article belongs to the Special Issue Functional Biomaterials for Regenerative Dentistry)
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