Novel Concepts, New Perspectives, and Current Therapies for Parkinson’s Disease: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 3928
Special Issue Editor
Interests: Parkinson’s disease; therapy; drug; repurposing; novel compound; neurodegeneration; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Parkinson’s disease (PD), the most common progressive, neurodegenerative movement disorder, is caused by a hypodopaminergic condition in the nigrostriatal system. Cardinal motor symptoms are the main determinant of the quality of life for those with PD, as well as the progression of the disability and possible nursing home placement. As life expectancy increases, the need for novel approaches to treat PD grows urgent. However, while most antiparkinsonian drugs offer symptomatic relief, they do not tackle the underlying etiology of the disease. In addition, there is currently no available therapy that slows down the progression of PD or even prevents its manifestation. The most significant limitations of approved drugs are mostly related to their side effects and lack of long-term efficacy. Therefore, driven by the increasing knowledge of neurodegeneration and neuroinflammation processes, extensive research efforts are underway to identify new strategies to modulate previously undruggable targets or to manage the disease.
The present Special Issue will highlight the state of current pharmacological strategies and explore drug candidates under treatment evaluation, as well as candidates for repurposing for the treatment of PD. Furthermore, this issue will also provide an overview of future studies and novel molecular targets that may be used to combat PD. Hence, for this Special Issue, we are inviting researchers to contribute original articles and reviews on these topics. Contributions from all research areas, including disease modeling, drug studies, and therapeutic interventions, are welcome.
I look forward to receiving your contributions.
Dr. Malgorzata Zaremba
Guest Editor
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Keywords
- Parkinson’s disease
- therapy
- drug
- repurposing
- novel compound
- neurodegeneration
- neuroinflammation
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