Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 5.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3163
Special Issue Editors
Interests: cytochrome P450
Special Issues, Collections and Topics in MDPI journals
Interests: drug metabolism; cytochrome P450 structure and mechanism; biological reactive intermediates; thiophene-S-oxides; arene oxides; sulfenic acid; mechanism based inhibitors; ferrocifen; drug induced immunotoxicity.
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of the previous four Special Issues in the “Cytochromes P450: Drug Metabolism and Bioactivation and Biodiversity” series 1–4 (https://www.mdpi.com/journal/ijms/special_issues/p450).
Nearly seventy year ago, R.T. Williams and B.B. Brodie developed the concept of drug metabolism and explored the types of reactions and the mechanisms that must occur in order for the body to facilitate the excretion of a drug. Ten years later, Klingenberg and Garfinkel independently discovered the P450 protein, which was, five years later, demonstrated to be a cytochrome P450 by Omura and Sato. Later on, the prominent function of this enzyme and its role in drug metabolism and endobiotics biosynthesis were established. This resulted in a new chapter, and now more than 90,000 papers make reference to cytochrome P450. We are now well aware of this enzyme’s importance in clearance and potential toxicity, and, therefore, compounds are frequently tested for it. Moreover, this enzyme family is widely distributed in the bacterial, animal, plant, alga and viral kingdoms.
Volumes 1–4 of “Cytochromes P450: Drug Metabolism and Bioactivation and Biodiversity” were considerably successful, with each publishing more than 10 papers. Thus, we have decided to launch a new Special Issue with an expanded range of allowed topics. This fifth Special Issue focuses on cytochrome P450’s drug metabolism, bioactivation and biodiversity and will include papers on (1) its structures, (2) types and mechanisms of reactions, (3) pharmacogenomics, (4) bioactivation reactions and biological markers, (5) mechanism-based inactivation, (6) species differences and (7) biodiversity.
We warmly welcome submissions, including original papers and reviews, on these widely-discussed topics.
Dr. Arthur Roberts
Dr. Patrick M. Dansette
Guest Editors
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Keywords
- cytochrome P450
- drug metabolism
- bioactivation
- pharmacogenomics
- reactive intermediates
- drug induced toxicity
- reaction mechanisms
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