Advanced Gels for Drug Delivery Systems Based on Sustainable Development Goals (SDGs) (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 1045

Special Issue Editors


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Guest Editor
1. National Institute of Chemical Physics and Biophysics, Tallinn, Estonia
2. Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy
3. Academy of History of Health Care Art, Rome, Italy
Interests: formulation science; polymer science; nanogels and hydrogels; drug delivery; interface and colloid science

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Guest Editor

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Guest Editor
Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, Milan, Italy
Interests: polymer functionalization; nanogels; hydrogels; colloids; drug delivery; cell delivery
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Special Issue Information

Dear Colleagues,

We are pleased to inform you that we are serving as the Guest Editors of a Gels Special Issue titled “Advanced Gels for Drug Delivery Systems Based on Sustainable Development Goals (SDGs) (2nd Edition)”. We would like to invite you to contribute your manuscript related to this topic.

Conventional gels are the classic pharmaceutical dosage forms usually used for topical treatment via skin route. In the last few decades, advanced gels have emerged and played a significant role in drug delivery systems, which is not limited to topical applications of drugs or cosmetics for local action. Advanced gels prepared by nanotechnology, such as vesicular gels, nanogels, emulgels, and so forth, have established their efficacy in terms of drug loading and the controlled release of drugs for different routes of administration (i.e., skin, oral, nose, brain, ocular, rectal, vaginal, etc.)

Many specific kinds of gels have been invented with potential for real-world application. For topical treatment, gels are developed to ensure adequate localization or penetration of the drug within or through the skin to enhance the local and minimize the systemic effects, or to ensure adequate percutaneous absorption. For systemic treatment, they are developed to increase the bioavailability of the drug through different routes and for many kinds of diseases. It is our pleasure to gather manuscripts covering all aspects, including formulation, manufacturing technologies, and current applications, in this Special Issue of Gels.

Dr. Stefano Scialla
Prof. Dr. Pierfrancesco Morganti
Dr. Emanuele Mauri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vesicular gels
  • nanogels
  • emulgels
  • hydrogels
  • organogels
  • in situ gels
  • stimuli-responsive gels
  • gel in water
  • bigels

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Published Papers (1 paper)

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20 pages, 688 KiB  
Systematic Review
Hydrogels Associated with Photodynamic Therapy Have Antimicrobial Effect against Staphylococcus aureus: A Systematic Review
by Ricardo S. Moura, João Pedro R. Afonso, Diego A. C. P. G. Mello, Renata Kelly Palma, Iransé Oliveira-Silva, Rodrigo F. Oliveira, Deise A. A. P. Oliveira, Dante B. Santos, Carlos Hassel M. Silva, Orlando A. Guedes, Giuseppe Insalaco and Luís V. F. Oliveira
Gels 2024, 10(10), 635; https://doi.org/10.3390/gels10100635 - 30 Sep 2024
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Abstract
Staphylococcus aureus (S. aureus) is a Gram-positive bacterium that causes infections ranging from mild superficial cases to more severe, potentially fatal conditions. Many photosensitisers used in photodynamic therapy are more effective against superficial infections due to limitations in treating deeper tissue [...] Read more.
Staphylococcus aureus (S. aureus) is a Gram-positive bacterium that causes infections ranging from mild superficial cases to more severe, potentially fatal conditions. Many photosensitisers used in photodynamic therapy are more effective against superficial infections due to limitations in treating deeper tissue infections. Recently, attention to this bacterium has increased due to the emergence of multidrug-resistant strains, which complicate antibiotic treatment. As a result, alternative therapies, such as antimicrobial photodynamic therapy (PDT), have emerged as promising options for treating non-systemic infections. PDT combines a photosensitiser (PS) with light and oxygen to generate free radicals that destroy bacterial structures. This systematic review evaluates the effectiveness of PDT delivered via different types of hydrogels in treating wounds, burns, and contamination by S. aureus. Following PRISMA 2020 guidelines, a bibliographic search was conducted in PubMed, Web of Science, and Scopus databases, including articles published in English between 2013 and 2024. Seven relevant studies were included, demonstrating evidence of PDT use against S. aureus in in vitro and in vivo studies. We concluded that PDT can effectively complement antimicrobial therapy in the healing of wounds and burns. The effectiveness of this technique depends on the PS used, the type of hydrogel, and the lesion location. However, further in vivo studies are needed to confirm the safety and efficacy of PDT delivered via hydrogels. Full article
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