Metabolic Alterations and Cellular Stress Responses in Chronic Obstructive Pulmonary Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 23956
Special Issue Editors
Interests: respiratory system; cell and molecular biology; mucosal immunology; asthma; COPD; regenerative medicine
Interests: COPD; DAMPs; innate immune system; cigarette smoke; biomarkers; cell death; RAGE
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
COPD is a severe and debilitating lung disease that is associated with high morbodity and mortality. Currently, no curative treatments are available. In order to identify novel therapeutic targets, it is important to understand the molecular and cellular mechanisms underlying the pathogenesis of COPD.
The primary focus of this Special Issue is to explore the metabolic alterations and cellular stress responses upon exposure to noxious particles in healthy and diseased lungs and how these contribute to the development of Accumulating evidence points towards the crucial role of cellular stress and alterations in the metabolic processes of structural and innate immune cells. Chronic inhalation of toxic gases and particles, including cigarette smoke, exhaust fumes, fine dust, and micro- and nanoplastics induces oxidative stress and cellular damage in the lungs. In combination with genetic susceptiblity and/or epigenetic modifications, this can ultimately lead to metabolic reprogramming in lung tissue as well as systemic changes leading to metalobic abnormalities. At the cellular level, COPD lungs display mitochondrial dysfunction, DNA damage, impaired proteasomal activity, and ER stress. This is associated with metabolic reprogramming, cell damage and death, and subsequent release of damage-associated molecular patterns (DAMPs), triggering immune and remodelling processes and systemic manifestations. We aim for the submission of review and research atricles that cover the latest findings in the field of metabolic alterations and cellular stress responses in COPD, including the effects of cigarette smoke and environmental pollutants; oxidative stress responses; mitochondrial dysfunction; mitophagy; the role of novel cell death modalities such as ferroptosis, necroptosis, NETosis, DAMP release; and systemic metabolic alterations.
Prof. Dr. Irene Heijink
Dr. Simon D. Pouwels
Guest Editors
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Keywords
- COPD
- oxidative stress
- metabolic alterations
- mitochondrial dysfunction
- proteasomal abnormalities and ER stress
- cell death modalities
- NETosis
- DAMPs
- DNA damage
- autophagy/mitophagy
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