Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation (Q28140199)

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scientific article (publication date: 16 November 2000)

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English	Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation	scientific article (publication date: 16 November 2000)

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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation (English)

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phosphorylation

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author name string

T Kamalati

1

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H E Jolin

2

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M J Fry

3

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M R Crompton

4

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language of work or name

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publication date

16 November 2000

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19

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48

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5471-6

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Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase.

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Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

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Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

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Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

1 reference

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The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

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The role of the epidermal growth factor receptor family in mammary tumorigenesis and metastasis

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Characterisation and chromosome mapping of the human non receptor tyrosine kinase gene, brk.

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Specificity within the EGF family/ErbB receptor family signaling network

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

1 reference

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Signaling by distinct classes of phosphoinositide 3-kinases

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A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

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BRK tyrosine kinase expression in a high proportion of human breast carcinomas

1 reference

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based on heuristic

inferred from DOI database lookup

Protein tyrosine kinases and cancer

1 reference

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7 January 2021

based on heuristic

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