Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice (Q27022347)

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12 December 2013

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14 February 2019

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12

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3119-41

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HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome

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Latent reservoirs of HIV: obstacles to the eradication of virus

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HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

21 March 2017

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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

21 March 2017

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Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation

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21 March 2017

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Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection

21 March 2017

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

21 March 2017

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Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

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Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1

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28 September 2017

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28 September 2017

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28 September 2017

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Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

28 September 2017

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Human hemato-lymphoid system mice: current use and future potential for medicine

28 September 2017

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Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

28 September 2017

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TALENs: a widely applicable technology for targeted genome editing

28 September 2017

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Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge

28 September 2017

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HIV-1 pathogenesis: the virus

28 September 2017

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Current progress of RNA aptamer-based therapeutics

28 September 2017

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Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice

28 September 2017

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Novel cell and gene therapies for HIV.

28 September 2017

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Topical gel formulation of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 confers protection against HIV-1 vaginal challenge in a humanized mouse model

28 September 2017

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Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses

28 September 2017

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Human B-cell ontogeny in humanized NOD/SCID γc(null) mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire

28 September 2017

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HIV Restriction Factors and Mechanisms of Evasion

28 September 2017

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

28 September 2017

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Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice

28 September 2017

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The enhancement of RNAi against HIV in vitro and in vivo using H-2K(k) protein as a sorting method

28 September 2017

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Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector.

28 September 2017

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RNA-based therapeutics: current progress and future prospects.

28 September 2017

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Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4(+) T cell resistance and enrichment

28 September 2017

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Humanized mice as a preclinical tool for infectious disease and biomedical research

28 September 2017

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Antibody-based protection against HIV infection by vectored immunoprophylaxis

28 September 2017

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Characterization of an HIV-targeted transcriptional gene-silencing RNA in primary cells

28 September 2017

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Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice

28 September 2017

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The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

28 September 2017

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Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement

28 September 2017

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Intracellular delivery of RNA-based therapeutics using aptamers

28 September 2017

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Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

28 September 2017

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Special delivery: targeted therapy with small RNAs.

28 September 2017

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Mice with human immune system components as in vivo models for infections with human pathogens

28 September 2017

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An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice

28 September 2017

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Stem cell-based anti-HIV gene therapy

28 September 2017

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Dimeric 2G12 as a potent protection against HIV-1.

28 September 2017

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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

28 September 2017

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TAL effectors: finding plant genes for disease and defense

28 September 2017

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RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

28 September 2017

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Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody

28 September 2017

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A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

28 September 2017

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Engineering antigen-specific T cells from genetically modified human hematopoietic stem cells in immunodeficient mice

28 September 2017

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Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

28 September 2017

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Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

28 September 2017

1 reference

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Specific transduction of HIV-susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization.

28 September 2017

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The challenge of finding a cure for HIV infection

28 September 2017

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Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

28 September 2017

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Long-term vector integration site analysis following retroviral mediated gene transfer to hematopoietic stem cells for the treatment of HIV infection

28 September 2017

1 reference

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Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice

28 September 2017

1 reference

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Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory act

28 September 2017

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Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition

28 September 2017

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Humanized mice in translational biomedical research

28 September 2017

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HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model

28 September 2017

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Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

28 September 2017

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T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.

28 September 2017

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Recombinant AAV2 transduction of primitive human hematopoietic stem cells capable of serial engraftment in immune-deficient mice

28 September 2017

1 reference

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Current status of gene therapy strategies to treat HIV/AIDS.

28 September 2017

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RNA-mediated inhibition of HIV in a gene therapy setting

28 September 2017

1 reference

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Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cell-derived macrophages

28 September 2017

1 reference

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RNA-based anti-HIV-1 gene therapeutic constructs in SCID-hu mouse model

28 September 2017

1 reference

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Gene therapy for pediatric AIDS.

28 September 2017

1 reference

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Ribozyme therapy for HIV infection

28 September 2017

1 reference

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Murine models for HIV disease.

28 September 2017

1 reference

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Human xenograft models for virus infection

28 September 2017

1 reference

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Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals

28 September 2017

1 reference

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RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication

28 September 2017

1 reference

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Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients

28 September 2017

1 reference

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Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes

28 September 2017

1 reference

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In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice

28 September 2017

1 reference

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Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.

31 May 2018

1 reference

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Generation of HIV-1 resistant and functional macrophages from hematopoietic stem cell-derived induced pluripotent stem cells

31 May 2018

1 reference

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Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects

31 May 2018

1 reference

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

31 May 2018

1 reference

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Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with hu

31 May 2018

1 reference

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Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model

21 January 2018

1 reference

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In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication

21 January 2018

1 reference

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Gene therapy using a simian virus 40-derived vector inhibits the development of in vivo human immunodeficiency virus type 1 infection of severe combined immunodeficiency mice implanted with human fetal thymic and liver tissue.

21 January 2018

1 reference

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Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo

21 January 2018

1 reference

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Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

21 January 2018

1 reference

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HIV evolution: CTL escape mutation and reversion after transmission

21 January 2018

1 reference

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Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals

21 January 2018

1 reference

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Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells

21 January 2018

1 reference

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Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients

21 January 2018

1 reference

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A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FV5123119

Patient monitoring and follow-up in lentiviral clinical trials

21 January 2018

1 reference

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A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FV5123119

T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FV5123119

Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FV5123119

Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells

21 January 2018

1 reference

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Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection

28 November 2018

1 reference

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A clinical trial of retroviral-mediated transfer of a rev-responsive element decoy gene into CD34(+) cells from the bone marrow of human immunodeficiency virus-1-infected children.

28 November 2018

1 reference

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Transfer of a functional human immune system to mice with severe combined immunodeficiency

28 November 2018

1 reference

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Infection of the SCID-hu mouse by HIV-1

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/24351796

12 December 2020

A marker study of therapeutically transduced CD4+ peripheral blood lymphocytes in HIV discordant identical twins

1 reference

https://pubmed.ncbi.nlm.nih.gov/24351796

12 December 2020

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24351796

12 December 2020

A phase I trial of autologous CD34+ hematopoietic progenitor cells transduced with an anti-HIV ribozyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/24351796

12 December 2020

Long-term survival and concomitant gene expression of ribozyme-transduced CD4+ T-lymphocytes in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24351796

12 December 2020

Identifiers

DOI

10.3390/V5123119

1 reference

release_4oryfu6b2nfl5ho5k4c3em4h5e

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

24351796

1 reference