Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases (Q33886716)

29 July 2017

title

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases (English)

1 reference

29 July 2017

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Craig B Wilen

1

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Philip D Gregory

Philip D Gregory

20

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James L. Riley

James L Riley

19

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Frederic D. Bushman

Frederic D Bushman

18

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Carl H. June

21

Carl H June

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29 July 2017

6

Edward J Rebar

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29 July 2017

23

Robert W Doms

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29 July 2017

16

James A Hoxie

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29 July 2017

Jianbin Wang

2

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29 July 2017

John C Tilton

3

1 reference

29 July 2017

Jeffrey C Miller

4

1 reference

29 July 2017

Kenneth A Kim

5

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29 July 2017

Scott A Sherrill-Mix

7

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29 July 2017

Sean C Patro

8

1 reference

29 July 2017

Anthony J Secreto

9

1 reference

29 July 2017

Andrea P O Jordan

10

1 reference

29 July 2017

Gary Lee

11

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29 July 2017

Joshua Kahn

12

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29 July 2017

Pyone P Aye

13

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29 July 2017

Bruce A Bunnell

14

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29 July 2017

Andrew A Lackner

15

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29 July 2017

Gwenn A Danet-Desnoyers

17

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29 July 2017

Michael C Holmes

22

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29 July 2017

language of work or name

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14 April 2011

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29 July 2017

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29 July 2017

volume

7

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29 July 2017

issue

4

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29 July 2017

page(s)

e1002020

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

14 April 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

28 July 2018

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RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma

28 July 2018

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28 July 2018

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28 July 2018

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HIV type 1 from a patient with baseline resistance to CCR5 antagonists uses drug-bound receptor for entry

28 July 2018

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28 July 2018

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Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature

28 July 2018

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Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

28 July 2018

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Baseline resistance of primary human immunodeficiency virus type 1 strains to the CXCR4 inhibitor AMD3100.

28 July 2018

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

28 July 2018

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Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

28 July 2018

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In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject

28 July 2018

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Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120.

28 July 2018

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Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.

28 July 2018

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An improved zinc-finger nuclease architecture for highly specific genome editing

28 July 2018

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HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211.

28 July 2018

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Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

28 July 2018

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T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery.

28 July 2018

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Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

28 July 2018

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Design, engineering, and characterization of zinc finger nucleases

28 July 2018

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

28 July 2018

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Targeted mutagenesis using zinc-finger nucleases in Arabidopsis

28 July 2018

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Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

28 July 2018

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Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistance

28 July 2018

1 reference

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Potent suppression of HIV type 1 infection by a short hairpin anti-CXCR4 siRNA.

28 July 2018

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Drug discovery with engineered zinc-finger proteins

28 July 2018

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Rapid, high-throughput engineering of sequence-specific zinc finger DNA-binding proteins

28 July 2018

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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

28 July 2018

1 reference

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Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers

28 July 2018

1 reference

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Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4

28 July 2018

1 reference

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CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2.

28 July 2018

1 reference

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Effect of mutations in the second extracellular loop of CXCR4 on its utilization by human and feline immunodeficiency viruses.

28 July 2018

1 reference

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Adenoviral-mediated gene transfer in lymphocytes.

28 July 2018

1 reference

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In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077364

Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3077364

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

28 July 2018

1 reference

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Change in coreceptor use correlates with disease progression in HIV-1--infected individuals

28 July 2018

1 reference

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

28 July 2018

1 reference

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Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

28 July 2018

1 reference

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Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

28 July 2018

1 reference

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Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation

28 July 2018

1 reference

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In vitro selection analysis of neomycin binding RNAs with a mutagenized pool of variants of the 16S rRNA decoding region

28 July 2018

1 reference

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Retained in vitro infectivity and cytopathogenicity of HIV-1 despite truncation of the C-terminal tail of the env gene product

28 July 2018

1 reference

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Entry inhibitors in the treatment of HIV-1 infection

28 July 2018

1 reference

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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

21 January 2018

1 reference

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

21 January 2018

1 reference

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Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002020

Characterization of anti-CCR5 ribozyme-transduced CD34+ hematopoietic progenitor cells in vitro and in a SCID-hu mouse model in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002020

Novel interfering bifunctional molecules against the CCR5 coreceptor are efficient inhibitors of HIV-1 infection

21 January 2018

1 reference

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Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells

21 January 2018

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Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy.

21 January 2018

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High-throughput SELEX SAGE method for quantitative modeling of transcription-factor binding sites.

21 January 2018

1 reference

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21 January 2018

V3: HIV's switch-hitter

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A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002020

Resistance of mature T cells to oncogene transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002020

Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1002020

Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity

21 January 2018

1 reference

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Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21533216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conversion of the FokI endonuclease to a universal restriction enzyme: cleavage of phage M13mp7 DNA at predetermined sites

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21533216

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PPAT.1002020

1 reference

29 July 2017

1 reference

29 July 2017

1 reference