An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice (Q35111705)

6 August 2017

title

An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice (English)

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6 August 2017

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8

Piotr Swiderski

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6 August 2017

10

Ramesh Akkina

1 reference

6 August 2017

Charles Preston Neff

1

1 reference

6 August 2017

Jiehua Zhou

2

1 reference

6 August 2017

Leila Remling

3

1 reference

6 August 2017

Jes Kuruvilla

4

1 reference

6 August 2017

Jane Zhang

5

1 reference

6 August 2017

Haitang Li

6

1 reference

6 August 2017

David D Smith

7

1 reference

6 August 2017

John J Rossi

9

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6 August 2017

language of work or name

English

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publication date

1 January 2011

1 reference

Science Translational Medicine

6 August 2017

published in

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6 August 2017

volume

3

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6 August 2017

issue

66

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6 August 2017

page(s)

66ra6

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Opportunistic bacterial infections in breeding colonies of the NSG mouse strain

6 August 2017

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Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year

9 July 2018

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Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.

9 July 2018

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The utilization of humanized mouse models for the study of human retroviral infections

9 July 2018

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Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

9 July 2018

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The chemical biology of aptamers

9 July 2018

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B cells in HIV infection and disease

9 July 2018

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Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

9 July 2018

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The challenge of finding a cure for HIV infection

9 July 2018

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The promises and pitfalls of RNA-interference-based therapeutics

9 July 2018

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Novel humanized murine models for HIV research

9 July 2018

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T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

9 July 2018

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Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

9 July 2018

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Quality scores and SNP detection in sequencing-by-synthesis systems

9 July 2018

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Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice

9 July 2018

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Genetic therapies against HIV.

9 July 2018

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Progress and prospects: RNA-based therapies for treatment of HIV infection.

9 July 2018

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Using aptamers to identify and enter cells.

9 July 2018

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HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model

9 July 2018

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

9 July 2018

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Aptamer:toxin conjugates that specifically target prostate tumor cells

9 July 2018

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Aptamer mediated siRNA delivery

9 July 2018

1 reference

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RNAi as a treatment for HIV-1 infection.

9 July 2018

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

9 July 2018

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

9 July 2018

1 reference

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

9 July 2018

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HIV-1-specific RNA interference.

9 July 2018

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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

9 July 2018

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siRNA-directed inhibition of HIV-1 infection

9 July 2018

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

9 July 2018

1 reference

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In vitro selection of RNA molecules that bind specific ligands

9 July 2018

1 reference

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Erratum: Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

9 July 2018

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Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3001581

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21248316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21248316

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.3001581

1 reference

6 August 2017

1 reference

6 August 2017

1 reference