Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? (Q24801684)

6 July 2017

1 reference

26 August 2020

Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play? (English)

1 reference

1-phosphatidylinositol 4-kinase

6 July 2017

1 reference

26 August 2020

1 reference

28 September 2019

1 reference

26 August 2020

1 reference

M J Fry

1

1 reference

6 July 2017

language of work or name

English

0 references

publication date

28 June 2001

6 references

6 July 2017

13 March 2019

3 April 2019

17 June 2019

28 September 2019

26 August 2020

Breast Cancer Research

6 references

6 July 2017

13 March 2019

3 April 2019

17 June 2019

28 September 2019

26 August 2020

3

1 reference

6 July 2017

issue

5

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6 July 2017

page(s)

304-312

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Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer

6 July 2017

cites work

1 reference

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Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

7 April 2017

1 reference

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

7 April 2017

1 reference

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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

7 April 2017

1 reference

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cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12

7 April 2017

1 reference

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Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

7 April 2017

1 reference

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Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

7 April 2017

1 reference

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The many substrates and functions of ATM

7 April 2017

1 reference

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Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance

7 April 2017

1 reference

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Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

7 April 2017

1 reference

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Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

PIK3CA as an oncogene in cervical cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Signaling by distinct classes of phosphoinositide 3-kinases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Phosphatidylinositol 3-kinases in tumor progression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

PI3-kinase inhibition: a target for drug development?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Phosphoinositide signaling and the regulation of membrane trafficking in yeast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.

28 September 2017

1 reference

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ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Distinct roles for the p110alpha and hVPS34 phosphatidylinositol 3'-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Heterozygous ATM mutations do not contribute to early onset of breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Structure, regulation and function of phosphoinositide 3-kinases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

Stabilization of cyclin D1 mRNA via the phosphatidylinositol 3-kinase pathway in MCF-7 human breast cancer cells.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FBCR312

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FBCR312

21 January 2018

[Rapamycin and CCI-779]

1 reference

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Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138693

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Estrogen receptor is associated with protein and phospholipid kinase activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Wortmannin, a phosphoinositide 3-kinase inhibitor, selectively enhances cytotoxicity of receptor-directed-toxin chimeras in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

BRK tyrosine kinase expression in a high proportion of human breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Phospatidylinositol 3-kinase expression in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene a

1 reference

https://pubmed.ncbi.nlm.nih.gov/11597319

12 December 2020

Identifiers

DOI

10.1186/BCR312

1 reference

Dimensions Publication ID

6 July 2017

1023379228

0 references

OpenCitations bibliographic resource ID

3406209

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

6 July 2017

1 reference