R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse (Q24621917)

9

Jonathan L Katz

0 references

Claus J Loland

1

Claus J Loland

0 references

Maddalena Mereu

2

Maddalena Mereu

0 references

Oluyomi M Okunola

3

Oluyomi M Okunola

0 references

Jianjing Cao

4

Jianjing Cao

0 references

Thomas E Prisinzano

5

Thomas E Prisinzano

0 references

Theresa Kopajtic

7

Theresa Kopajtic

0 references

Gianluigi Tanda

10

Gianluigi Tanda

0 references

author name string

Sonia Mazier

6

0 references

Lei Shi

Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals

8

0 references

language of work or name

English

0 references

publication date

1 September 2012

0 references

published in

Biological Psychiatry

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volume

72

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issue

5

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page(s)

405-13

0 references

cites work

1 reference

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Mechanisms of modafinil: A review of current research

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Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications

7 April 2017

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Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil

7 April 2017

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

7 April 2017

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X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

7 April 2017

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The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors

7 April 2017

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Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies

7 April 2017

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Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

7 April 2017

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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

7 April 2017

1 reference

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Modafinil for the treatment of methamphetamine dependence

7 April 2017

1 reference

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Cognitive enhancers in the treatment of substance use disorders: clinical evidence

27 September 2017

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Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2-[(diphenylmethyl)sulfinyl]acetamide) Analogues

27 September 2017

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Neuroscience of behavioral and pharmacological treatments for addictions

27 September 2017

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Translational research in addiction: toward a framework for the development of novel therapeutics

27 September 2017

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Lost in translation: neuropsychiatric drug development

27 September 2017

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N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects

27 September 2017

1 reference

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Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys

27 September 2017

1 reference

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The binding sites for benztropines and dopamine in the dopamine transporter overlap.

27 September 2017

1 reference

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Modulatory effects of modafinil on neural circuits regulating emotion and cognition

27 September 2017

1 reference

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Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents

27 September 2017

1 reference

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Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.

27 September 2017

1 reference

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The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

27 September 2017

1 reference

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Modafinil does not serve as a reinforcer in cocaine abusers

27 September 2017

1 reference

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27 September 2017

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Modafinil: a useful medication for cocaine addiction? Review of the evidence from neuropharmacological, experimental and clinical studies.

27 September 2017

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Development of pharmacotherapies for drug addiction: a Rosetta stone approach

27 September 2017

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Combinations of cocaine with other dopamine uptake inhibitors: assessment of additivity

27 September 2017

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Modafinil reinstates a cocaine conditioned place preference following extinction in rats

27 September 2017

1 reference

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An intracellular interaction network regulates conformational transitions in the dopamine transporter.

27 September 2017

1 reference

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Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

27 September 2017

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Modafinil: a review of neurochemical actions and effects on cognition

27 September 2017

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Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants

27 September 2017

1 reference

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A systematic review of modafinil: Potential clinical uses and mechanisms of action

27 September 2017

1 reference

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Novel procedure for modeling ligand/receptor induced fit effects.

27 September 2017

1 reference

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Modafinil: preclinical, clinical, and post-marketing surveillance--a review of abuse liability issues.

27 September 2017

1 reference

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Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.

27 September 2017

1 reference

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Clinical pharmacokinetic profile of modafinil

27 September 2017

1 reference

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Cognitive enhancing effects of modafinil in healthy volunteers

27 September 2017

1 reference

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Acute behavioral and physiological effects of modafinil in drug abusers

27 September 2017

1 reference

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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

27 September 2017

1 reference

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Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?

27 September 2017

1 reference

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Permeation and gating residues in serotonin transporter

27 September 2017

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Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

27 September 2017

1 reference

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Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens

27 September 2017

1 reference

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Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: a randomized, open-label, crossover study

27 September 2017

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Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.

30 May 2018

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The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter

30 May 2018

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Evaluation of the cocaine-like discriminative stimulus effects and reinforcing effects of modafinil

30 May 2018

1 reference

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Novel 4'-substituted and 4',4"-disubstituted 3 alpha-(diphenylmethoxy)tropane analogs as potent and selective dopamine uptake inhibitors

30 May 2018

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A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence

30 May 2018

1 reference

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Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro

28 November 2018

1 reference

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Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss

28 November 2018

1 reference

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Reinforcing effects of modafinil: influence of dose and behavioral demands following drug administration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413742

Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

28 November 2018

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Chiral analysis of d- and l-modafinil in human serum: application to human pharmacokinetic studies

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413742

Study of the addictive potential of modafinil in naive and cocaine-experienced rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413742

An evaluation of the abuse potential of modafinil using methylphenidate as a reference

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413742

A double-blind, placebo-controlled, ascending-dose evaluation of the pharmacokinetics and tolerability of modafinil tablets in healthy male volunteers

28 November 2018

1 reference

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Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism

28 November 2018

1 reference

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Modafinil binds to the dopamine uptake carrier site with low affinity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413742

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22537794

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A Systematic Review of Modafinil

1 reference

Crossref

https://api.crossref.org/works/10.1016%2FJ.BIOPSYCH.2012.03.022

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.BIOPSYCH.2012.03.022

1 reference

1 reference

1 reference

PubMed publication ID

22537794

1 reference