The binding sites for cocaine and dopamine in the dopamine transporter overlap (Q24650126)

1

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Julie Kniazeff

2

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Marianne L Bergmann

3

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Lei Shi

4

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Luis Gracia

5

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Klaudia Raniszewska

6

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Jonathan A Javitch

8

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Harel Weinstein

9

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Ulrik Gether

10

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Claus J Loland

LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

11

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language of work or name

English

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publication date

July 2008

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published in

Nature Neuroscience

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volume

11

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issue

7

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page(s)

780-9

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cites work

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Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter

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Neurotransmitter transporters and their impact on the development of psychopharmacology

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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

7 April 2017

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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

7 April 2017

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Neurotransmitter transporters: molecular function of important drug targets

7 April 2017

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The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands

7 April 2017

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Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6

7 April 2017

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Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition

7 April 2017

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Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

7 April 2017

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Cocaine receptors on dopamine transporters are related to self-administration of cocaine

7 April 2017

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Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

7 April 2017

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Mechanism of chloride interaction with neurotransmitter:sodium symporters.

28 September 2017

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How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation

28 September 2017

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Glutamate and monoamine transporters: new visions of form and function

28 September 2017

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Historical and current perspectives of neuroactive compounds derived from Latin America

28 September 2017

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Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter

28 September 2017

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

28 September 2017

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Neuropsychiatric effects of cocaine use disorders

28 September 2017

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Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants

28 September 2017

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A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

28 September 2017

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A comprehensive atlas of the topography of functional groups of the dopamine transporter

28 September 2017

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A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate

28 September 2017

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Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue

28 September 2017

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The top 20 dopamine transporter mutants: structure–function relationships and cocaine actions

28 September 2017

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Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole

28 September 2017

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Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism

28 September 2017

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Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

28 September 2017

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The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

28 September 2017

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Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter

28 September 2017

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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

28 September 2017

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Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter

28 September 2017

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Proximity of transmembrane domains 1 and 3 of the gamma-aminobutyric acid transporter GAT-1 inferred from paired cysteine mutagenesis

28 November 2018

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Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.

28 November 2018

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Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands

28 November 2018

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Molecular model of the neural dopamine transporter

28 November 2018

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Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.

28 November 2018

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Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.

28 November 2018

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Importance of valine at position 152 for the substrate transport and 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane binding of dopamine transporter.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2692229

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

28 November 2018

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Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition.

28 November 2018

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Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

28 November 2018

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A putative model of the dopamine transporter.

28 November 2018

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A Flexible Docking Procedure for the Exploration of Peptide Binding Selectivity to Known Structures and Homology Models of PDZ Domains

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18568020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18568020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNN.2146

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NN.2146

1 reference

Dimensions Publication ID

1032831529

0 references

1 reference

1 reference

PubMed publication ID

18568020

1 reference