Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. (Q36254171)

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English	Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.	scientific article

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13 November 2019

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter (English)

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13 November 2019

Jonathan Javitch

2

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13 November 2019

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J V Ferrer

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13 November 2019

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1 August 1998

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13 November 2019

Proceedings of the National Academy of Sciences of the United States of America

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13 November 2019

95

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13 November 2019

16

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13 November 2019

9238-9243

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13 November 2019

The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

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The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain

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On the use of thiol-modifying agents to determine channel topology

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Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis

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Molecular characterization of the dopamine transporter.

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Neurotransmitter transporters: recent progress

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30 September 2017

Residues in the pathway through a membrane transporter

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Short external loops as potential substrate binding site of gamma-aminobutyric acid transporters

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30 September 2017

Cocaine receptors on dopamine transporters are related to self-administration of cocaine

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Transmembrane protein structure: spin labeling of bacteriorhodopsin mutants

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30 September 2017

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

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30 September 2017

Cloning and expression of a cocaine-sensitive rat dopamine transporter

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30 September 2017

Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

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30 September 2017

Cloning of the cocaine-sensitive bovine dopamine transporter

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30 September 2017

The dopamine hypothesis of the reinforcing properties of cocaine

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30 September 2017

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

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30 September 2017

Cocaine and dopamine differentially protect [3H]mazindol binding sites from alkylation by N-ethylmaleimide

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30 September 2017

Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.

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30 September 2017

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

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30 September 2017

Families of twelve transmembrane domain transporters

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30 September 2017

Determination of transmembrane protein structure by disulfide cross-linking: the Escherichia coli Tar receptor

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30 September 2017

Antipeptide antibodies confirm the topology of the human norepinephrine transporter

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30 September 2017

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

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Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein.

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29 June 2018

Dopamine transporter mutants selectively enhance MPP+ transport

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29 June 2018

Mercuric chloride and p-chloromercuriphenylsulfonate exert a biphasic effect on the binding of the stimulant [3H]methylphenidate to the dopamine transporter

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29 June 2018

Effect of CH3HgCl and several transition metals on the dopamine neuronal carrier; peculiar behaviour of Zn2+.

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29 June 2018

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

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29 June 2018

Interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3H]GBR 12783 and [3H]cocaine binding sites.

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Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate

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Putative cocaine receptor in striatum is a glycoprotein with active thiol function.

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Site-directed mutagenesis of colicin E1 provides specific attachment sites for spin labels whose spectra are sensitive to local conformation.

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N-ethylmaleimide irreversibly inhibits the binding of [3H]threo-(+-)-methylphenidate to the stimulant recognition site

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29 June 2018

Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis.

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29 June 2018

A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs

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Radiolabeling of dopamine uptake sites in mouse striatum: comparison of binding sites for cocaine, mazindol, and GBR 12935

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21 January 2018

Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier.

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Binding domains for blockers and substrates on the dopamine transporter in rat striatal membranes studied by protection against N-ethylmaleimide-induced reduction of [3H]WIN 35,428 binding

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Topological localization of cysteine 74 in the GABA transporter, GAT1, and its importance in ion binding and permeation.

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Analysis of the transmembrane topology and membrane assembly of the GAT-1 gamma-aminobutyric acid transporter

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Effects of sulfhydryl reagents on the Cys65 mutant of the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli.

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Zinc modulation of drug binding, cocaine affinity states, and dopamine uptake on the dopamine uptake complex

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22 September 2018

Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression.

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External cysteine residues in the serotonin transporter

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Histidine 225, a residue of the NhaA-Na+/H+ antiporter of Escherichia coli is exposed and faces the cell exterior

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Electrostatic potential of the acetylcholine binding sites in the nicotinic receptor probed by reactions of binding-site cysteines with charged methanethiosulfonates

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21 January 2018

Determination of external loop topology in the serotonin transporter by site-directed chemical labeling

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21 January 2018

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/9689064

12 December 2020

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10.1073/PNAS.95.16.9238

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13 November 2019

1998PNAS...95.9238F

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13 November 2019

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13 November 2019

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