Search Results (85)

Nano-encapsulation and conjugation are the main strategies employed for drug delivery. Nanoparticles help improve encapsulation and targeting efficiency, thus optimizing therapeutic efficacy. Through nanoparticle technology, replacement of a defective gene or delivery of a new gene into a patient’s genome has become possible. Lipid nanoparticles (LNPs) loaded with genetic materials are designed to be delivered to specific target sites to enable gene therapy. The lipid shells protect the fragile genetic materials from degradation, then successfully release the payload inside of the cells, where it can integrate into the patient’s genome and subsequently express the protein of interest. This review focuses on the development of LNPs and nano-pharmaceutical techniques for improving the potency of gene therapies, reducing toxicities, targeting specific cells, and releasing genetic materials to achieve therapeutic effects. In addition, we discuss preparation techniques, encapsulation efficiency, and the effects of conjugation on the efficacy of LNPs in delivering nucleic acid materials. Full article

The skin is the largest organ in the human body and serves multiple functions such as barrier protection and thermoregulation. The maintenance of its integrity and healthy structure is of paramount importance. Accordingly, technological advances in cosmetic sciences have been directed towards optimizing these factors. Plant-derived ingredients have been explored for their bioactivity profiles and sustainable sources. Grape by-products contain a group of bioactive molecules that display important biological activities. Nonetheless, many of these molecules (e.g., phenolic compounds) are unstable and susceptible to degradation. So, their encapsulation using nano/microsystems (i.e., microdispersions) has been explored as a promising solution. In this work, two grape seed extracts were obtained, one from a single grape variety (GSE-Ov) and another from a mix of five grape varieties (GSE-Sv). These extracts were analysed for their antioxidant and antimicrobial activities, as well as their chemical composition and molecular structure. The extract that showed the most promising properties was GSE-Ov with a DPPH IC₅₀ of 0.079 mg mL⁻¹. This extract was encapsulated in soy lecithin microdispersions coated with pectin, with an encapsulation efficiency of 88.8%. They showed an in vitro release of polyphenols of 59.4% during 24 h. The particles displayed a zeta potential of −20.3 mV and an average diameter of 13.6 µm. Microdispersions proved to be safe under 5 and 2.5 mg mL⁻¹ in HaCaT and HDF cell models, respectively. Additionally, they demonstrated anti-inflammatory activity against IL-1α when tested at 2 mg mL⁻¹. This work enabled the valorisation of a by-product from the wine industry by using natural extracts in skincare products. Full article

Agrochemicals can now be protected from harsh environments like pH, light, temperature, and more with the help of a drug-loading system. This has allowed the creation of targeted and continuous release functions for pesticides and fertilizers, as well as the precise application, reduction, and efficiency of agrochemicals. All of these benefits have been made possible by the recent advancements in the field of nanomaterials. A simple procedure known as electrospinning can be used to create nanofibers from natural and synthetic polymers. Nanofibers have come to be recognized as one of the sustainable routes with enormous applicability in different fields. In agriculture, a promising strategy may entail plant protection and growth through the encapsulating of numerous bio-active molecules as pesticides and fertilizers for intelligent administration at the desired places. Owing to their permeability, tiny dimensions, and large surface area, nanofibers can regulate the rate at which agrochemicals are released. This slows down the rate at which the fertilizer dissolves and permits the release of coated fertilizer gradually over time, which is more effectively absorbed by plant roots, as well as the efficiency of pesticides. Thus, modern agriculture requires products and formulations that are more efficient and environmentally friendly than traditional agrochemicals. In addition to highlighting the significance and originality of using nanofibers and offering a brief explanation of the electrospinning technology, the review article’s main goal is to provide a thorough summary of the research leading to breakthroughs in the nanoencapsulation of fertilizers and pesticides. Full article

The building envelope serves as a barrier against climatic conditions and as insulation to prevent energy waste within buildings. As global energy shortages become more pressing, the requirements for building envelopes are becoming increasingly stringent. Among the available technologies, phase change materials (PCMs) stand out for their high latent thermal energy storage and temperature stabilization capabilities. This paper reviews the recent advancements in PCM technology for building envelopes, starting with an overview of organic, inorganic, and eutectic PCMs, along with their respective advantages and disadvantages. The paper explores various incorporation methods such as shape stabilization, macroencapsulation, micro/nanoencapsulation, and solid–solid transition techniques. The integration of PCMs enhances thermal inertia, reduces thermal fluctuations, and delays heat peaks, presenting several multifunctional benefits. However, challenges such as fire hazards, potential toxicity, pollution, reduced mechanical performance, and higher initial costs persist. In light of these challenges, criteria for PCM integration in building applications are introduced. Additionally, the paper reviews recent hybrid technologies that combine PCMs with other novel technologies for building envelopes, including radiant temperature regulation systems, thermochromic windows, passive radiative cooling coatings, and others. It is shown that these PCM-integrated hybrid technologies significantly improve energy savings and indoor comfort. PCMs offer substantial potential for modern green building strategies and have further applications in other building contexts. Finally, the paper provides future prospects for studies in this field, aiming towards a green and energy-saving future. Full article

Plant proteins have gained significant attention over animal proteins due to their low carbon footprint, balanced nutrition, and high sustainability. These attributes make plant protein nanocarriers promising for applications in drug delivery, nutraceuticals, functional foods, and other areas. Zein, a major by-product of corn starch processing, is inexpensive and widely available. Its unique self-assembly characteristics have led to its extensive use in various food and drug systems. Zein’s functional tunability allows for excellent performance in loading and transporting bioactive substances. Lutein offers numerous bioactive functions, such as antioxidant and vision protection, but suffers from poor chemical stability and low bioavailability. Nano-embedding technology can construct various zein-loaded lutein nanodelivery systems to address these issues. This review provides an overview of recent advances in the construction of zein-loaded lutein nanosystems. It discusses the fundamental properties of these systems; systematically introduces preparation techniques, structural characterization, and functional properties; and analyzes and predicts the target-controlled release and bioaccessibility of zein-loaded lutein nanosystems. The interactions and synergistic effects between Zein and lutein in the nanocomplexes are examined to elucidate the formation mechanism and conformational relationship of zein–lutein nanoparticles. The physical and chemical properties of Zein are closely related to the molecular structure. Zein and its modified products can encapsulate and protect lutein through various methods, creating more stable and efficient zein-loaded lutein nanosystems. Additionally, embedding lutein in Zein and its derivatives enhances lutein’s digestive stability, solubility, antioxidant properties, and overall bioavailability. Full article

In recent years, astaxanthin as a natural substance has received widespread attention for its potential to replace traditional synthetic antioxidants and because its antioxidant activity exceeds that of similar substances. Based on this, this review introduces the specific forms of astaxanthin currently used as an antioxidant in foods, both in its naturally occurring forms and in artificially added forms involving technologies such as emulsion, microcapsule, film, nano liposome and nano particle, aiming to improve its stability, dispersion and bioavailability in complex food systems. In addition, research progress on the application of astaxanthin in various food products, such as whole grains, seafood and poultry products, is summarized. In view of the characteristics of astaxanthin, such as insolubility in water and sensitivity to light, heat, oxygen and humidity, the main research trends of astaxanthin-loaded systems with high encapsulation efficiency, good stability, good taste masking effect and cost-effectiveness are also pointed out. Finally, the possible sensory effects of adding astaxanthin to food aresummarized, providing theoretical support for the development of astaxanthin-related food. Full article

Already used in the food, pharmaceutical, cosmetic, and agrochemical industries, encapsulation is a strategy used to protect active ingredients from external degradation factors and to control their release kinetics. Various encapsulation techniques have been studied, both to optimise the level of protection with respect to the nature of the aggressor and to favour a release mechanism between diffusion of the active compounds and degradation of the barrier material. Biopolymers are of particular interest as wall materials because of their biocompatibility, biodegradability, and non-toxicity. By forming a stable hydrogel around the drug, they provide a ‘smart’ barrier whose behaviour can change in response to environmental conditions. After a comprehensive description of the concept of encapsulation and the main technologies used to achieve encapsulation, including micro- and nano-gels, the mechanisms of controlled release of active compounds are presented. A panorama of natural polymers as wall materials is then presented, highlighting the main results associated with each polymer and attempting to identify the most cost-effective and suitable methods in terms of the encapsulated drug. Full article

Plant-parasitic nematodes (PPNs) reduce the high profitability of many crops and degrade their quantitative and qualitative yields globally. Traditional nematicides and other nematode control methods are being used against PPNs. However, stakeholders are searching for more sustainable and effective alternatives with limited side effects on the environment and mankind to face increased food demand, unfavorable climate change, and using unhealthy nematicides. This review focuses on upgrading the pre-procedures of PPN control as well as novel measures for their effective and durable management strategies on economically important crops. Sound and effective sampling, extraction, identification, and counting methods of PPNs and their related microorganisms, in addition to perfecting designation of nematode–host susceptibility/resistance, form the bases for these strategies. Therefore, their related frontiers should be expanded to synthesize innovative integrated solutions for these strategies. The latter involve supplanting unsafe nematicides with a new generation of safe and reliable chemical nematicidal and bionematicidal alternatives. For better efficacy, nematicidal materials and techniques should be further developed via computer-aided nematicide design. Bioinformatics devices can reinforce the potential of safe and effective biocontrol agents (BCAs) and their active components. They can delineate the interactions of bionematicides with their targeted PPN species and tackle complex diseases. Also, the functional plan of nematicides based on a blueprint of the intended goals should be further explored. Such goals can currently engage succinate dehydrogenase, acetylcholinesterase, and chitin deacetylase. Nonetheless, other biochemical compounds as novel targets for nematicides should be earnestly sought. Commonly used nematicides should be further tested for synergistic or additive function and be optimized via novel sequential, dual-purpose, and co-application of agricultural inputs, especially in integrated pest management schemes. Future directions and research priorities should address this novelty. Meanwhile, emerging bioactivated nematicides that offer reliability and nematode selectivity should be advanced for their favorable large-scale synthesis. Recent technological means should intervene to prevail over nematicide-related limitations. Nanoencapsulation can challenge production costs, effectiveness, and manufacturing defects of some nematicides. Recent progress in studying molecular plant–nematode interaction mechanisms can be further exploited for novel PPN control given related topics such as interfering RNA techniques, RNA-Seq in BCA development, and targeted genome editing. A few recent materials/techniques for control of PPNs in durable agroecosystems via decision support tools and decision support systems are addressed. The capability and effectiveness of nematicide operation harmony should be optimized via employing proper cooperative mechanisms among all partners. Full article

The discovery of antibiotics and pesticides has greatly contributed to the social and economic development of human society but, due to the long-term irrational application, it has led to drug-resistant microorganisms, environmental damage, and other hazards, so the selection of alternative natural, safe, and non-hazardous bioactive substances is an effective solution for this problem. D-limonene is a bioactive compound widely present in various plant essential oils, exhibiting excellent broad-spectrum bioactivity and promising prospects for development and clinical application. This review provides a detailed overview of the biological activities of D-limonene, emphasizing its antimicrobial, anthelmintic, insecticidal, and medicinal potential. While nanoencapsulation technology shows promise in improving the physicochemical properties of D-limonene and enhancing its practical applications, it is also crucial to comprehensively evaluate the potential side effects of D-limonene before use. Full article

Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nanodelivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nanoencapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nanoencapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nanoencapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes. Full article

Encapsulation and drying technologies allow the engineering of innovative raw materials from plant biodiversity, with potential applications in pharmaceutical and cosmetic fields. Lipid-based nanoencapsulation stands out for its efficiency, ease of production, and versatility in encapsulating substances, whether hydrophilic or lipophilic. This work aimed at encapsulating pequi oil in liposomes and freeze-dried liposomes to enhance its stability and functional benefits, such as skin hydration and anti-aging effects, for use in innovative cosmetic formulations. Pequi oil—extracted from the Caryocar brasiliense fruit pulp, a plant species from Brazilian plant biodiversity—is rich in secondary metabolites and fatty acids. Liposomes and dried liposomes offer controlled production processes and seamless integration into cosmetic formulations. The physicochemical analysis of the developed liposomes confirmed that the formulations are homogeneous and electrokinetically stable, as evidenced by consistent particle size distribution and zeta potential values, respectively. The gel-type formulations loaded with the dried liposomes exhibit enhanced skin hydration, improved barrier function, and refined microrelief, indicating improvements in skin conditions. These results highlight the potential of dried liposomes containing pequi oil for the development of innovative cosmeceutical products. This research contributes to the valorization of Brazilian biodiversity by presenting an innovative approach to leveraging the dermatological benefits of pequi oil in cosmetic applications. Full article

Gallic acid–Antarctic krill peptides (GA-AKP) nanocapsules (GA-AKP-Ns) were prepared using a dual delivery system with complex emulsion as the technical method, a high-pressure microjet as the technical means, polylactic acid–hydroxyacetic acid (PLGA) as the drug delivery vehicle, and GA-AKP as the raw material for delivery. This study aimed to investigate the effects of microjet treatment and the concentration of PLGA on the physicochemical properties and stability of the emulsion. Under optimal conditions, the physicochemical properties and hypoglycemic function of nano-microcapsules prepared after lyophilization by the solvent evaporation method were analyzed. Through the microjet treatment, the particle size of the emulsion was reduced, the stability of the emulsion was improved, and the encapsulation rate of GA-AKP was increased. The PLGA at low concentrations decreased the particle size of the emulsion, while PLGA at high concentrations enhanced the encapsulation efficiency of the emulsion. Additionally, favorable results were obtained for emulsion preparation through high-pressure microjet treatment. After three treatment cycles with a PLGA concentration of 20 mg/mL and a microjet pressure of 150 MPa (manometric pressure), the emulsion displayed the smallest particle size (285.1 ± 3.0 nm), the highest encapsulation rates of GA (71.5%) and AKP (85.2%), and optimal physical stability. GA-AKP was uniformly embedded in capsules, which can be slowly released in in vitro environments, and effectively inhibited α-amylase, α-glucosidase, and DPP-IV at different storage temperatures. This study demonstrated that PLGA as a carrier combined with microjet technology can produce excellent microcapsules, especially nano-microcapsules, and these microcapsules effectively improve the bioavailability and effectiveness of bioactive ingredients. Full article

Water deficit (WD) promotes great losses in agriculture, and the development of new sustainable technologies to mitigate the effects of this stress on plants is essential. This study aimed to evaluate the morphophysiological and biochemical alterations induced by the priming of tomato seeds with different formulations in plants under field capacity and WD conditions. In the first experiment, the treatments consisted of nanoparticles of alginate/chitosan and chitosan/tripolyphosphate containing gibberellic acid (GA₃) in different concentrations (0.5, 5, and 50 µg mL⁻¹ GA₃), in addition to control with deionized water. The alginate/chitosan (5 µg mL⁻¹ GA₃) provided the greatest gains in plant growth under field capacity. In addition, under WD this treatment reduced damage to photosystem II (−14%), stomatal conductance (−13%), and water loss (−38%) and increased the instantaneous carboxylation efficiency (+24%) and intrinsic water use efficiency (+12%). In the second experiment, the treatments were alginate/chitosan nanoparticles containing GA₃ (NPGA₃ 5 µg mL⁻¹), free GA₃ (GA₃ 5 µg mL⁻¹), nanoparticles without GA₃ (NP), deionized water (WATER), and non-primed seeds (CONT). Under WD, GA₃ and CONT maintained plant growth and lost water rapidly, reducing stomatal conductance (−87%) and net photosynthesis (−69%). In contrast, NPGA₃ decreased leaf area (−44%) and increased root-to-shoot ratio (+39%) when compared to GA₃, reducing water loss (−28%). Activation of protective mechanisms (e.g., superoxide dismutase and catalase activities) by WATER, NPGA₃, and NP treatments also resulted in lower susceptibility to WD compared to CONT and GA₃. The results highlight the positive effect of seed priming on plant response to WD, which was enhanced by the use of nanoencapsulated GA₃. Full article

Smart self-healing coatings offer a revolutionary approach to mitigating metal corrosion, a problem with significant economic and environmental impacts. Divided into intrinsic and extrinsic types, these coatings autonomously rectify the damage. Intrinsic variants utilize reversible bonds to achieve ongoing repair, while extrinsic ones incorporate micro/nanocontainers that activate upon environmental triggers to mend micro-cracks, their efficacy dictated by the encapsulated healing agents’ volume. This review dissects the rapidly evolving sector of stimuli-responsive self-healing coatings, emphasizing the progress in micro/nano container technology. It discusses the synthesis and encapsulation processes of different micro/nanocontainers and charts the transition from single to multistimulus-responsive systems, which enhances the coatings’ sensitivity and functionality. The addition of multifunctional traits such as self-reporting and anti-microbial actions further broadens their industrial applicability. The review provides a succinct overview of the field’s current state and future potential, envisioning a paradigm shift in corrosion protection through advanced smart coatings. Full article

Sisal fiber exhibits a fibrous and porous structure with significant surface roughness, making it highly suitable for storing phase change materials (PCMs). Its intricate morphology further aids in mitigating the risk of PCM leakage. This research successfully employs vacuum adsorption to encapsulate paraffin within sisal fiber, yielding a potentially cost-effective, durable, and environmentally friendly phase change energy storage medium. A systematic investigation was carried out to evaluate the effects of sisal-to-paraffin mass ratio, fiber length, vacuum level, and negative pressure duration on the loading rate of paraffin. The experimental results demonstrate that a paraffin loading rate of 8 wt% can be achieved by subjecting a 3 mm sisal fiber to vacuum adsorption with 16 wt% paraffin for 1 h at −0.1 MPa. Through the utilization of nano-CT imaging enhancement technology, along with petrographic microscopy, this study elucidates the mechanism underlying paraffin storage within sisal fiber during vacuum adsorption. The observations reveal that a substantial portion of paraffin is primarily stored within the pores of the fiber, while a smaller quantity is firmly adsorbed onto its surface, thus yielding a durable phase change energy storage medium. The research findings contribute to both the theoretical foundations and the available practical guidance for the fabrication and implementation of paraffin/sisal fiber composite phase change energy storage mediums. Full article