The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review
Abstract
:1. Introduction
2. Astrocytes are Intimately Associated with Ion Channels
2.1. Diverse Functions of Voltage-Gated Ca2+ Signals in Astrocytes
2.2. Role of the Big Conductance K+ (BK) Channel in Astrocytes
3. Astrocytes are Intimately Associated with Neuronal Functions
3.1. Synapse Formation and Elimination by Astrocytes
3.2. Astrocytes-Mediated Protein Aggregates Regulation
3.3. Mitochondria Functions in Astrocyte–Neuron Crosstalk
3.4. Effects of Astrocytic HIF-1α on Neurovascular Functions
3.5. Astrocytes and Oxidative/Nitrosative Stress
4. Astrocytes and Diseases
4.1. Alzheimer’s Disease
4.2. Parkinson’s Disease
4.3. Stroke
5. Therapeutic Effects of HO Metabolites in CNS Injury
5.1. Carbon Monoxide
5.2. BR
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Kim, Y.; Park, J.; Choi, Y.K. The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review. Antioxidants 2019, 8, 121. https://doi.org/10.3390/antiox8050121
Kim Y, Park J, Choi YK. The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review. Antioxidants. 2019; 8(5):121. https://doi.org/10.3390/antiox8050121
Chicago/Turabian StyleKim, Yonghee, Jinhong Park, and Yoon Kyung Choi. 2019. "The Role of Astrocytes in the Central Nervous System Focused on BK Channel and Heme Oxygenase Metabolites: A Review" Antioxidants 8, no. 5: 121. https://doi.org/10.3390/antiox8050121