Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Ethics Statement
2.2. Animals and Protocols
2.3. Measurement of Metabolic Parameters
2.4. Measurement of Superoxide Anion
2.5. Adipocyte Morphometry
2.6. UCP-1 Protein Immuno-Staining
2.7. Statistical Analysis
3. Results
3.1. Blood Pressure
3.2. Body Weight in Relation to the Weight of Epididymis and Pancreas
3.3. Metabolic Parameters
3.4. Oxidative Stress
3.5. Number and Size of Epididymal Adipocyte Cells
3.6. Epididymal UCP-1 Protein Staining
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Data availability
Abbreviations
References
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Metabolic Parameters | ZL | ZL + LA | ZDF | ZDF + LA |
---|---|---|---|---|
Final body weight(g) | 312 ± 6 | 305 ± 6 | 365 ± 9 ** | 326 ± 5 ## |
Plasma glucose (mmol/L) | 5.8 ± 0.4 | 5.3 ± 0.3 | 16.8 ± 1.8 ** | 12.9 ± 1.7 ** |
Plasma insulin (pmol/L) | 471.5 ± 36.5 | 520.6 ± 130.2 | 2098.9 ± 313.5 ** | 2087.0 ± 253.9 ** |
HOMA | 18.0 ± 1.9 | 17.5 ± 4.3 | 271.9 ± 30.9 ** | 182.4 ± 50.9 ** |
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El Midaoui, A.; Fantus, I.G.; Ait Boughrous, A.; Couture, R. Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats. Antioxidants 2019, 8, 648. https://doi.org/10.3390/antiox8120648
El Midaoui A, Fantus IG, Ait Boughrous A, Couture R. Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats. Antioxidants. 2019; 8(12):648. https://doi.org/10.3390/antiox8120648
Chicago/Turabian StyleEl Midaoui, Adil, I. George Fantus, Ali Ait Boughrous, and Réjean Couture. 2019. "Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats" Antioxidants 8, no. 12: 648. https://doi.org/10.3390/antiox8120648