Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects
Abstract
:Simple Summary
Abstract
1. Introduction
2. Classification of the Ionic TRP Channels
2.1. TRP Families and Subfamilies
2.1.1. Classification of TRP
2.1.2. TRPV (Vanilloid)
2.1.3. TRPM (Melastatin-Related)
2.1.4. TRPA (Ankyrin)
2.1.5. TRPN (No Mechanoreceptor Potential-C)
2.1.6. TRPP (Polycystin)
2.1.7. TRPML (Mucolipin)
2.1.8. TRPVL (Vanilloid-like)
2.1.9. TRPC (Canonical)
2.1.10. TRPS (Soromelastatin)
2.1.11. TRPY (Fungus-Specific TRP Channel)
2.2. Temperature-Sensitive TRP
3. Structure
4. Neurophysiology
4.1. The Opening/Closing Mechanism of TRP Channels
4.1.1. Membrane Voltage
4.1.2. Membrane Phospholipids
4.1.3. Phosphorylation
4.1.4. Ligands
5. Heat-Sensitive TRP
5.1. Harmful Heat
5.1.1. TRPV1
5.1.2. TRPV2
5.2. Harmless Heat
5.2.1. TRPV3
5.2.2. TRPV4
5.2.3. TRPM2, TRPM4, and TRPM5
6. Cold-Sensitive TRP
6.1. Harmful Cold
TRPA1
6.2. Harmless Cold
6.2.1. TRPM8
6.2.2. TRPC5
7. Uses of TRP in Disease Treatment
8. Areas of Opportunity
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Lezama-García, K.; Mota-Rojas, D.; Pereira, A.M.F.; Martínez-Burnes, J.; Ghezzi, M.; Domínguez, A.; Gómez, J.; de Mira Geraldo, A.; Lendez, P.; Hernández-Ávalos, I.; et al. Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects. Animals 2022, 12, 106. https://doi.org/10.3390/ani12010106
Lezama-García K, Mota-Rojas D, Pereira AMF, Martínez-Burnes J, Ghezzi M, Domínguez A, Gómez J, de Mira Geraldo A, Lendez P, Hernández-Ávalos I, et al. Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects. Animals. 2022; 12(1):106. https://doi.org/10.3390/ani12010106
Chicago/Turabian StyleLezama-García, Karina, Daniel Mota-Rojas, Alfredo M. F. Pereira, Julio Martínez-Burnes, Marcelo Ghezzi, Adriana Domínguez, Jocelyn Gómez, Ana de Mira Geraldo, Pamela Lendez, Ismael Hernández-Ávalos, and et al. 2022. "Transient Receptor Potential (TRP) and Thermoregulation in Animals: Structural Biology and Neurophysiological Aspects" Animals 12, no. 1: 106. https://doi.org/10.3390/ani12010106