New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View
Abstract
:1. Introduction
2. Thermoreceptors Implicated in Pain Transduction
2.1. TRPV1
2.1.1. TRPV1 Pharmacology
2.2. TRPA1
2.2.1. TRPA1 Pharmacology
2.3. TRPM8
2.3.1. TRPM8 Pharmacology
2.4. TRPV2
2.4.1. TRPV2 Pharmacology
2.5. TRPV3
2.5.1. TRPV3 Pharmacology
2.6. TRPV4
2.6.1. TRPV4 Pharmacology
3. New Therapeutic Approaches Targeting Thermo-TRP
3.1. Activity-Dependent Modulators: Open Channel Blockers
3.2. Modulation of Protein-Protein Interactions: TRPducins
3.3. Modulators of TRP Trafficking
4. Conclusions
Acknowledgments
Conflict of Interest
References and Notes
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Fernández-Carvajal, A.; Fernández-Ballester, G.; Devesa, I.; González-Ros, J.M.; Ferrer-Montiel, A. New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View. Pharmaceuticals 2012, 5, 16-48. https://doi.org/10.3390/ph5010016
Fernández-Carvajal A, Fernández-Ballester G, Devesa I, González-Ros JM, Ferrer-Montiel A. New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View. Pharmaceuticals. 2012; 5(1):16-48. https://doi.org/10.3390/ph5010016
Chicago/Turabian StyleFernández-Carvajal, Asia, Gregorio Fernández-Ballester, Isabel Devesa, José Manuel González-Ros, and Antonio Ferrer-Montiel. 2012. "New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View" Pharmaceuticals 5, no. 1: 16-48. https://doi.org/10.3390/ph5010016