The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion
Abstract
:1. Introduction
2. Curcumin Bioactivity and Characterization
2.1. Antioxidation
2.2. Anti-Inflammatory
2.3. Low Bioavailability
3. Curcumin Modulates the Gut Microbiota
3.1. Curcumin Affects the Abundance of Beneficial Bacteria
3.2. Curcumin Affects the Intestinal Barrier
4. Dysregulation of Gut Microbial Ecology and Related Diseases
4.1. Disorders of Lipid Metabolism
Obesity
4.2. Immune System
4.2.1. Atherosclerosis
4.2.2. Inflammatory Bowel Disease
5. Curcumin in the Treatment of Related Diseases
5.1. Curcumin Improves Obesity
5.2. Curcumin Cures Atherosclerosis
5.3. Curcumin Relieves IBD
6. Conclusions and Prospects
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Diseases | Curcumin Dose | Duration | Effects | Reference |
---|---|---|---|---|
Metabolic syndrome | 1 g/day | 8 weeks | ↓TNF-α, IL-6 and MCP-1 | [7] |
Obesity | 1 g/day | 4 weeks | ↓IL-1β, IL-4, VGEF | [8] |
Diabetes | 500 mg/day | 15–30 days | ↓ Oxidation | [9] |
Atherosclerosis | 0.5 g/day | 7 days | ↓ Serum lipid peroxides and serum total cholesterol levels ↑ HDL cholesterol | [10] |
Colorectal cancer | 1.08 g/day | 10–30 days | ↓ TNF-α ↑ p53 expression and improve BMI | [11] |
Rheumatoid arthritis | 1.2 g/day | 2 weeks | Improvement in joint swelling, morning stiffness | [12] |
Fatty liver disease | 1 g/day | 8 weeks | ↓ BMI ↑ Liver function | [13] |
Levels | Functions | Reference | |
---|---|---|---|
Phylum | Firmicutes | Produces beneficial SCFAs Maintains balanced gut flora Supports intestinal barrier integrity | [61,62,63,64] |
Bacteroidetes | Secretes antimicrobial substances Balances nutrients in the gut Supports immune system functioning | ||
Proteobacteria | Produces beneficial SCFAs | ||
Actinobacteria | Promotes bioactive substances Inhibits pathogenic bacteria Produces acetic acid and butyric acid | ||
Family | Bacteroidaceae | Breaks down polysaccharides Aids absorption | [61,62,63,64,65,66] |
Prevotellaceae | Produces acetic acid | ||
Bifidobacteriaceae | Maintains intestinal microbial balance | ||
Lactobacillaceae | Secretes sIgA produces acids | ||
Enterobacteriaceae | Produces beneficial SCFAs | ||
Micromonosporaceae | Supports immune system health | ||
Genus | Bacteroides | Secretes sIgA | [61,62,63,64,65,66,67,68] |
Prevotella | Produces beneficial SCFAs | ||
Bifidobacterium | Maintains flora balance | ||
Escherichia | Involved in degradation and fermentation of proteins and fibers |
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Zhu, J.; He, L. The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion. Microorganisms 2024, 12, 642. https://doi.org/10.3390/microorganisms12040642
Zhu J, He L. The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion. Microorganisms. 2024; 12(4):642. https://doi.org/10.3390/microorganisms12040642
Chicago/Turabian StyleZhu, Junwen, and Lan He. 2024. "The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential Strategy for Disease Treatment and Health Promotion" Microorganisms 12, no. 4: 642. https://doi.org/10.3390/microorganisms12040642