Antimicrobial Peptides: Multifunctional Drugs for Different Applications
Abstract
:1. Introduction
Family Class Human example Localization References |
---|
Defensins α-defensin HNP-1-4, Neutrophils, NK cells [30] |
HD-5, HD-6 Paneth cells |
β-defensin HBD-1-4 widely distributed [31] |
leukocytes and |
epithelial cells, |
for example: tongue, |
skin, cornea, salivary glands, |
kidneys, esophagus |
and respiratory tract |
θ-defensin not determined in leukocytes of primates [32] |
Cathelicidins LL-37 widely distributed [33] |
leukocytes and |
epithelial cells, |
for example: |
epithelia of skin, gut |
and lungs |
and brain tissue |
Histatins HIS-1, 3 or 5 saliva, submandibular [34] |
sublingual and |
parotid glands |
2. Diversity of Functions
2.1. Antimicrobial Activity
2.2. Immunomodulatory and Further Activities
3. Practical Applications
4. Conclusions and Future Perspectives
Acknowledgments
References
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Brandenburg, L.-O.; Merres, J.; Albrecht, L.-J.; Varoga, D.; Pufe, T. Antimicrobial Peptides: Multifunctional Drugs for Different Applications. Polymers 2012, 4, 539-560. https://doi.org/10.3390/polym4010539
Brandenburg L-O, Merres J, Albrecht L-J, Varoga D, Pufe T. Antimicrobial Peptides: Multifunctional Drugs for Different Applications. Polymers. 2012; 4(1):539-560. https://doi.org/10.3390/polym4010539
Chicago/Turabian StyleBrandenburg, Lars-Ove, Julika Merres, Lea-Jessica Albrecht, Deike Varoga, and Thomas Pufe. 2012. "Antimicrobial Peptides: Multifunctional Drugs for Different Applications" Polymers 4, no. 1: 539-560. https://doi.org/10.3390/polym4010539