Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats
Abstract
:1. Introduction
2. Results
2.1. MDMA Administration Did Not Affect NADPH Oxidase Immunoreactivity
2.2. MDMA Administration Induced an Increase in iNOS Immunoreactivity
2.3. MDMA Administration Induced an Increase in NT Immunoreactivity
2.4. MDMA and NT Were Localized in Dopaminergic Neurons
2.5. MDMA and NT Were Not Localized in Glia Cells
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. MDMA Administration and Experimental Protocol
4.3. Immunohistochemical Analyses
4.4. Blindness of the Study
4.5. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Antibodies | Colors |
MDMA/DT1 | Red/Blue-grey |
NT/DT1 | Purple/Blue-grey |
MDMA/NOX2 | Purple/Blue-grey |
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Schiavone, S.; Neri, M.; Maffione, A.B.; Frisoni, P.; Morgese, M.G.; Trabace, L.; Turillazzi, E. Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats. Int. J. Mol. Sci. 2019, 20, 1242. https://doi.org/10.3390/ijms20051242
Schiavone S, Neri M, Maffione AB, Frisoni P, Morgese MG, Trabace L, Turillazzi E. Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats. International Journal of Molecular Sciences. 2019; 20(5):1242. https://doi.org/10.3390/ijms20051242
Chicago/Turabian StyleSchiavone, Stefania, Margherita Neri, Angela Bruna Maffione, Paolo Frisoni, Maria Grazia Morgese, Luigia Trabace, and Emanuela Turillazzi. 2019. "Increased iNOS and Nitrosative Stress in Dopaminergic Neurons of MDMA-Exposed Rats" International Journal of Molecular Sciences 20, no. 5: 1242. https://doi.org/10.3390/ijms20051242