Матеріал з Вікіпедії — вільної енциклопедії.
PTEN
Ідентифікатори
Символи PTEN Зовнішні ІД
OMIM : 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN
Пов'язані генетичні захворювання
head and neck squamous cell carcinoma , macrocephaly-autism syndrome , Cowden syndrome 1 , multiple hamartoma syndrome , prostate adenocarcinoma , меланома , prostate carcinoma , Bannayan-Riley-Ruvalcaba syndrome , Proteus-like syndrome [ 1]
Онтологія гена Молекулярна функція
• phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • enzyme binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • identical protein binding • hydrolase activity • lipid binding • ubiquitin-specific protease binding • ionotropic glutamate receptor binding • protein tyrosine kinase binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • PDZ domain binding
Клітинна компонента
• цитоплазма • postsynaptic membrane • extracellular region • мітохондрія • neuron projection • cytoplasmic side of plasma membrane • клітинне ядро • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • apical plasma membrane • клітинна мембрана • PML body • нуклеоплазма • гіалоплазма • postsynaptic cytosol
Біологічний процес
• multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • Ангіогенез • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • Довготривале пригнічення • positive regulation of excitatory postsynaptic potential • проліферація • response to ethanol • neuron projection development • cellular response to hypoxia • negative regulation of cell size • negative regulation of cell population proliferation • prepulse inhibition • regulation of myeloid cell apoptotic process • male mating behavior • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • пам'ять • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • learning or memory • соціальна поведінка • synapse assembly • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of dendritic spine morphogenesis • brain morphogenesis • GO:0033128 negative regulation of protein phosphorylation • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • GO:0016576 protein dephosphorylation • protein stabilization • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • response to glucose • нейробіологія розвитку • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • GO:0098501, GO:0098502, GO:0006286 дефосфорилювання • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • lipid metabolism • GO:0010260 старіння людини • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell population proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • cell migration • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • central nervous system neuron axonogenesis • довготривала потенціація • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity • protein deubiquitination • negative regulation of epithelial to mesenchymal transition • negative regulation of keratinocyte migration • cellular response to electrical stimulus • negative regulation of wound healing, spreading of epidermal cells • negative regulation of phosphatidylinositol 3-kinase signaling • GO:1901313 positive regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • response to activity • cellular response to insulin stimulus • cellular response to leptin stimulus • positive regulation of neuron differentiation • cellular response to ethanol • negative regulation of potassium ion transmembrane transporter activity • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • negative regulation of signaling receptor activity • negative regulation of protein kinase B signaling • GO:0097285 апоптоз • negative regulation of cell migration • regulation of protein stability • negative regulation of focal adhesion assembly • negative regulation of vascular associated smooth muscle cell proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of neuron projection development
Джерела:Amigo / QuickGO
Ортологи
Види
Людина Миша Entrez Ensembl UniProt RefSeq (мРНК)
RefSeq (білок)
Локус (UCSC)
Хр. 10: 87.86 – 87.97 Mb Хр. 19: 32.73 – 32.8 Mb PubMed search[ 2] [ 3] Вікідані
PTEN , ген гомологу фосфатази та тензину (англ. Phosphatase and tensin homolog ) – білок, який кодується геном PTEN , розташованим у людей на довгому плечі 10-ї хромосоми (10q23).[ 4] амінокислот , а молекулярна маса — 47 166[ 5] ліпідну фосфатазу , яка відповідає за регуляцію сигнального шляху PI3K . За рахунок цього стає можливим блокування клітиного циклу в фазі G1 та апоптоз . PTEN є супресором пухлин, негативно активований при багатьох типах злоякісних пухлин та асоційований зокрема з синдромом Коудена , одним з великих симптомів якого є фолікулярний рак щитоподібної залози [ 6]
Послідовність амінокислот
10 20 30 40 50 MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res . 14 : 2121—2127. 2004. PMID 15489334 DOI :10.1101/gr.2596504 Maehama T., Dixon J.E. (1998). The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem . 273 : 13375—13378. PMID 9593664 DOI :10.1074/jbc.273.22.13375 Georgescu M.-M., Kirsch K.H., Akagi T., Shishido T., Hanafusa H. (1999). The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region. Proc. Natl. Acad. Sci. U.S.A . 96 : 10182—10187. PMID 10468583 DOI :10.1073/pnas.96.18.10182 Torres J., Pulido R. (2001). The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation. J. Biol. Chem . 276 : 993—998. PMID 11035045 DOI :10.1074/jbc.M009134200 Miller S., Lou D., Seldin D., Lane W., Neel B. (2002). Direct identification of PTEN phosphorylation sites. FEBS Lett . 528 : 145—153. PMID 12297295 DOI :10.1016/S0014-5793(02)03274-X Okahara F., Ikawa H., Kanaho Y., Maehama T. (2004). Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein. J. Biol. Chem . 279 : 45300—45303. PMID 15355975 DOI :10.1074/jbc.C400377200
