AmiGO 2: Term Details for "canonical Wnt signaling pathway" (GO:0060070)

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Term Information

Accession: GO:0060070
Name: canonical Wnt signaling pathway
Ontology: biological_process
Synonyms: Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin, canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway
Alternate IDs: None
Definition: A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. Source: PMID:11532397, PMID:19619488
Comment: None
History: See term history for GO:0060070 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to canonical Wnt signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to canonical Wnt signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for canonical Wnt signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0016055 Wnt signaling pathway
GO:0060070 canonical Wnt signaling pathway
GO:1904886 beta-catenin destruction complex disassembly
GO:1990907 beta-catenin-TCF complex
GO:0061316 canonical Wnt signaling pathway involved in heart development
GO:0044338 canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
GO:1990909 Wnt signalosome

Parents of canonical Wnt signaling pathway (GO:0060070)

subject	relation	object
canonical Wnt signaling pathway	is_a	Wnt signaling pathway (GO:0016055)

Children of canonical Wnt signaling pathway (GO:0060070)

subject	relation	object
beta-catenin-TCF complex (GO:1990907)	RO:0002216	canonical Wnt signaling pathway
Wnt signalosome (GO:1990909)	RO:0002216	canonical Wnt signaling pathway
regulation of canonical Wnt signaling pathway (GO:0060828)	RO:0002211	canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway (GO:0090263)	RO:0002213	canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336)	is_a	canonical Wnt signaling pathway
beta-catenin destruction complex disassembly (GO:1904886)	BFO:0000050	canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in heart development (GO:0061316)	is_a	canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of apoptotic process (GO:0044337)	is_a	canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway (GO:0090090)	RO:0002212	canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation (GO:0044338)	is_a	canonical Wnt signaling pathway

Reactome: R-HSA-4641262