(Q34450092)

2 August 2017

1 reference

title

Molecular mechanisms of cellular transformation by HTLV-1 Tax. (English)

1 reference

Human T-lymphotropic virus 1

2 August 2017

main subject

0 references

1

Ralph Grassmann

1 reference

2 August 2017

3

Kuan-Teh Jeang

1 reference

2 August 2017

Mordechai Aboud

2

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 September 2005

1 reference

2 August 2017

1 reference

2 August 2017

volume

24

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2 August 2017

issue

39

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2 August 2017

page(s)

5976-5985

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Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site

2 August 2017

cites work

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Functional role of pX open reading frame II of human T-lymphotropic virus type 1 in maintenance of viral loads in vivo

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Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding

21 January 2018

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Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex

21 January 2018

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Redox events in HTLV-1 Tax-induced apoptotic T-cell death

21 January 2018

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IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1.

21 January 2018

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Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. Critical role of arginine residues.

21 January 2018

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Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells

21 January 2018

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Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells

21 January 2018

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Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax.

21 January 2018

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Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector

21 January 2018

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Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells

21 January 2018

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IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein

21 January 2018

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p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex

21 January 2018

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Suppression of the transformed phenotype in hybrids of human T-cell leukemia virus type I tax-transformed rat fibroblasts and normal human fibroblasts

21 January 2018

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Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function

21 January 2018

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A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.

21 January 2018

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A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha

21 January 2018

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Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein

21 January 2018

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Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

21 January 2018

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Two discrete events, human T-cell leukemia virus type I Tax oncoprotein expression and a separate stress stimulus, are required for induction of apoptosis in T-cells

21 January 2018

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p21(Waf1/Cip1/Sdi1) prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human T-cell leukemia virus type 1-encoded tax.

21 January 2018

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The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells

21 January 2018

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Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia

21 January 2018

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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells

21 January 2018

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Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

21 January 2018

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Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

21 January 2018

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Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase

21 January 2018

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Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line

21 January 2018

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Human T-lymphotropic virus type 1 oncoprotein tax promotes S-phase entry but blocks mitosis

21 January 2018

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HTLV-I Tax directly binds the Cdc20-associated anaphase-promoting complex and activates it ahead of schedule

21 January 2018

1 reference

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Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks

21 January 2018

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

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Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site

21 January 2018

1 reference

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Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Evidence for NF-kappaB- and CBP-independent repression of p53's transcriptional activity by human T-cell leukemia virus type 1 Tax in mouse embryo and primary human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

The spindle checkpoint: structural insights into dynamic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Differential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

The HTLV-I tax protein transcriptionally modulates OX40 antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway

21 January 2018

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From polyploidy to aneuploidy, genome instability and cancer

21 January 2018

1 reference

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Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

21 January 2018

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Activation of HTLV-I long terminal repeat by stress-inducing agents and protection of HTLV-I-infected T-cells from apoptosis by the viral tax protein

21 January 2018

1 reference

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Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.

21 January 2018

1 reference

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Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease

21 January 2018

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Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes

21 January 2018

1 reference

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7 January 2021

Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration

1 reference

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7 January 2021

Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis.

1 reference

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7 January 2021

High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-kappaB-CBP ternary complex in the cytoplasm.

1 reference

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7 January 2021

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1 reference

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7 January 2021

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax.

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7 January 2021

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34

1 reference

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7 January 2021

The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins

1 reference

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7 January 2021

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300

1 reference

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7 January 2021

Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells

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7 January 2021

Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

1 reference

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7 January 2021

Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP.

1 reference

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7 January 2021

ICE-proteases mediate HTLV-I Tax-induced apoptotic T-cell death.

1 reference

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7 January 2021

Human T‐cell leukemia virus type 1 Tax activates cyclin‐dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53‐independent mechanism: Inhibition of cdk2

1 reference

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7 January 2021

Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.

1 reference

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7 January 2021

X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro

1 reference

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7 January 2021

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Inactivation of hTERT transcription by Tax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis.

1 reference

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7 January 2021

Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis

1 reference

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7 January 2021

Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

The HTLV-1 tax oncoprotein attenuates DNA damage induced G1 arrest and enhances apoptosis in p53 null cells

1 reference

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7 January 2021

Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL).

1 reference

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7 January 2021

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-kappa B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

p53-independent induction of apoptosis by the HTLV-I tax protein following UV irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Interleukin-4 and interleukin-13 signaling connections maps

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Direct binding of the N-terminus of HTLV-1 tax oncoprotein to cyclin-dependent kinase 4 is a dominant path to stimulate the kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Significance of multiple mutations in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Influence of human T-cell leukemia virus type I tax and rex on interleukin-2 gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Cell cycle dysregulation by HTLV-I: role of the tax oncoprotein

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7 January 2021

Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-I associated myelopathy, a new clinical entity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity.

1 reference

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7 January 2021

Microsatellite instability: the mutator that mutates the other mutator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.

1 reference

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7 January 2021

Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax.

1 reference

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7 January 2021

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells

1 reference

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7 January 2021

Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapy

1 reference

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7 January 2021

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

1 reference

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7 January 2021

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.

1 reference

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7 January 2021

Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309.

1 reference

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7 January 2021

Stimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein.

1 reference

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7 January 2021

Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

The role of CREB as a proto-oncogene in hematopoiesis and in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Interleukin-13 overexpression by tax transactivation: a potential autocrine stimulus in human T-cell leukemia virus-infected lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208978

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208978

1 reference

Dimensions Publication ID

2 August 2017

1037554462

0 references

1 reference