(Q44013190)

English

Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function

scientific article published on 31 May 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 November 2017

Characterization of regions in hsMAD1 needed for binding hsMAD2. A polymorphic change in an hsMAD1 leucine zipper affects MAD1-MAD2 interaction and spindle checkpoint function (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

author name string

Yoichi Iwanaga

1

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Takefumi Kasai

2

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Karen Kibler

3

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Kuan-Teh Jeang

4

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

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publication date

31 May 2002

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Europe PubMed Central

PubMed publication ID

28 November 2017

number of pages

9

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Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

28 November 2017

277

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Europe PubMed Central

PubMed publication ID

28 November 2017

34

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

31005-31013

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

Mitotic checkpoints: from yeast to cancer

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MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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Mutations of mitotic checkpoint genes in human cancers

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Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells

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Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

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Mitotic checkpoint locus MAD1L1 maps to human chromosome 7p22 and mouse chromosome 5

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Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

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CENP-E as an essential component of the mitotic checkpoint in vitro.

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CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint

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Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation

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21 January 2018

The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Aneuploidy and cancer

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Identification of a human mitotic checkpoint gene: hsMAD2

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The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

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Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines

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Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer

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The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis

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Chromosome defects in the colon

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Identifiers

10.1074/JBC.M110666200

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 November 2017

ResearchGate publication ID

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