(Q45150040)

10 December 2017

title

Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL). (English)

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10 December 2017

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Hatta Y

1

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10 December 2017

Koeffler HP

series ordinal

2

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10 December 2017

publication date

1 June 2002

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10 December 2017

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10 December 2017

volume

16

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10 December 2017

issue

6

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10 December 2017

page(s)

1069-1085

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Adult T cell leukaemia cells are of CD4+ CDw29+ T cell origin and secrete a B cell differentiation factor

10 December 2017

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Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia

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Alteration of p16 (CDKN2) gene is associated with interleukin-2-induced tumor cell growth in adult T-cell leukemia

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Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells

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Methylation of the p16INK4A gene in multiple myeloma

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Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma

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Molecular analysis of a family of cyclin-dependent kinase inhibitor genes (p15/MTS2/INK4b and p18/INK4c) in non-small cell lung cancers

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Analysis of p18INK4C in adult T-cell leukaemia and non-Hodgkin's lymphoma

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Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms

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HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

p21 is a universal inhibitor of cyclin kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Absence of mutations and identification of two polymorphisms in the SSCP and sequence analysis of p21CK1 gene in malignant gliomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

p21WAF1 mutations and human malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Constitutive expression of B-myb can bypass p53-induced Waf1/Cip1-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

A cooperative interaction of human T-cell leukemia virus type 1 Tax with the p21 cyclin-dependent kinase inhibitor activates the human immunodeficiency virus type 1 enhancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

The pattern of p53 and p21WAF1/CIP1 immunoreactivity in non-Hodgkin's lymphomas predicts p53 gene status

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

How p53 suppresses cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

New link found between p53 and DNA repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Genetic Alteration of p53 in Some Patients with Adult T-Cell Leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Adult T-cell leukemia: structures and expression of the p53 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

The p53 tumour suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Role of the retinoblastoma gene in the initiation and progression of human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Altered expression of the retinoblastoma susceptibility gene in chronic lymphocytic leukaemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Aberrations of p16Ink4 and retinoblastoma tumour-suppressor genes occur in distinct sub-sets of human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutation of a mutL homolog in hereditary colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mutations of GTBP in genetically unstable cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Meiotic pachytene arrest in MLH1-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Microsatellite instability during the progression of acute myelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Microsatellite instability in primary neoplasms from HIV+ patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Microsatellite instability in adult T-cell leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Genomic instability occurs in colorectal carcinomas but not in adenomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Hereditary non-polyposis colorectal cancer — morphologies, genes and mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Cancer family “G” revisited: 1895-1970

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies.Clinical description

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies.II. Chromosomal and immunologic abnormalities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Small bowel cancers, B-cell lymphatic leukemia, and six primary cancers with metastases and prolonged survival in the cancer family syndrome of Lynch.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Clues to the pathogenesis of familial colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Cytogenetic implication in adult T-cell leukemia. A hypothesis of leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

IL-2 receptor dysfunction and adult T-cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402458

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402458

1 reference

Dimensions Publication ID

10 December 2017

1029840960

0 references

1 reference