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Clinical oncology

Section edited by: Prof Serigne Magueye Gueye and Prof Jan Vermorken. 

The clinical oncology section represents an opportunity to share experiences and information among worldwide oncologists and to identify and develop diagnostic as well as therapeutic protocols, which are globally valid in the current global village. Potential topics include, but are not limited to: epidemiology, pathology and pathogenesis of cancers and clinical studies

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  1. Human papillomavirus (HPV) infection is recognized as one of the major causes of infection-related cancer worldwide. In Spain, the HPV vaccination program started in 2007 and until 2022, it targeted 12-year-ol...

    Authors: Noelia López, Ignacio Salamanca de la Cueva, Elena Taborga, Auxiliadora Fernández de Alba, Inés Cabeza, Reyes Mazas Raba, Josep Marès, Patricia Company, Bruno Herrera and Manuel Cotarelo
    Citation: Infectious Agents and Cancer 2022 17:55
    Content type: Research Article Published on:

  2. Cervical cancer prevention for older women can be challenging since there are no specific guidelines for this group. This study aimed to determine the incidence of oncogenic HPV and HPV-related dysplasia in elder...

    Authors: Ruth S. Hermansson, Matts Olovsson, Inger Gustavsson, Ulf Gyllensten, Olga Lindkvist, Julia Hedlund Lindberg, Gabriella Lillsunde-Larsson and Annika K. Lindström
    Citation: Infectious Agents and Cancer 2022 17:42
    Content type: Research Article Published on:

  3. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) accounts for more than half of total HCC patients in developing countries. Currently, HBV-related HCC diagnosis and prognosis still lack specific ...

    Authors: Yi-Min Hu, Ruoxi Ran, Chaoqi Yang and Song-Mei Liu
    Citation: Infectious Agents and Cancer 2022 17:34
    Content type: Research Article Published on:

  4. High recurrence rate was a major factor for the poor postoperative prognosis of hepatocellular carcinoma (HCC) patients. The present study was intended to evaluate the association of gamma-glutamyl transpeptid...

    Authors: Zeping Li, Lili Liang, Wen Duan, Chengmao Zhou and Jian-Jun Yang
    Citation: Infectious Agents and Cancer 2022 17:16
    Content type: Research Article Published on:

  6. In populations with high rates of human immunodeficiency virus (HIV)-coinfection, the nature of the relationship between human papillomavirus (HPV)-16 and -18 (L1, E6 and E7) antibodies and cervical cancer is ...

    Authors: Mwiza Gideon Singini, Elvira Singh, Debbie Bradshaw, Wenlong Carl Chen, Melitah Motlhale, Abram Bunya Kamiza, Chantal Babb de Villiers, Mazvita Muchengeti, Christopher G. Mathew, Robert Newton, Noemi Bender, Tim Waterboer and Freddy Sitas
    Citation: Infectious Agents and Cancer 2022 17:14
    Content type: Research Article Published on:

  8. Sexually transmitted infections (STIs) are prevalent throughout the world and impose a significant burden on individual health and public health systems. Missed diagnosis and late treatment of STIs can lead to...

    Authors: Zhihai Ma, Baback Gharizadeh, Xingsheng Cai, Mengzhen Li, María Dolores Fellner, Jorge Alejandro Basiletti, Rita Mariel Correa, María Celeste Colucci, Gabriela Baldoni, Martín Vacchino, Patricia Galarza, María Alejandra Picconi and Chunlin Wang
    Citation: Infectious Agents and Cancer 2022 17:9
    Content type: Methodology Published on:

  10. The possible association of human papillomavirus (HPV) and bladder cancer has been controversial. Older findings suggest a significant association between the virus and bladder cancer. The aim of this study wa...

    Authors: Alireza Khatami, Zahra Salavatiha and Mohammad Hossein Razizadeh
    Citation: Infectious Agents and Cancer 2022 17:3
    Content type: Research Article Published on:

  11. Earlier I hypothesized that hereditary tumors might participate in the evolution of multicellular organisms. I formulated the hypothesis of evolution by tumor neofunctionalization, which suggested that the evo...

    Authors: A. P. Kozlov
    Citation: Infectious Agents and Cancer 2022 17:2
    Content type: Review Published on:

  12. Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial cells of the nasopharyngeal mucosa of the head and neck. The role of long non-coding RNA and RNA methylation in NPC has recei...

    Authors: Jiaojiao Peng, Hong Zheng, Feng Liu, Qi Wu and Shixi Liu
    Citation: Infectious Agents and Cancer 2022 17:1
    Content type: Research Article Published on:

  13. Infectious diseases are a major cause of morbidity and mortality among cancer patients. We aimed to determine the incidence of infectious diseases as a cause of death among cancer patients and analyze the tren...

    Authors: Muhammed Elhadi, Ala Khaled and Ahmed Msherghi
    Citation: Infectious Agents and Cancer 2021 16:72
    Content type: Research Article Published on:

  14. Cervical cancers are closely associated with persistent high-risk human papillomaviruses (HR HPV) infection. The main mechanism involves the targeting of tumor suppressors, such as p53 and pRB, for degradation...

    Authors: Yinghui Wang, Yihang Xie, Boxuan Sun, Yuwei Guo, Ling Song, Dawit Eman Mohammednur and Chunyan Zhao
    Citation: Infectious Agents and Cancer 2021 16:71
    Content type: Research Article Published on:

  15. Gastric cancer is the third leading cause of cancer-related deaths worldwide and has been associated with infections that may promote tumour progression. Accordingly, we analysed the presence of Mollicutes, Mycop...

    Authors: Camila do Nascimento Araujo, Aline Teixeira Amorim, Maysa Santos Barbosa, Julieta Canjimba Porto Lucas Alexandre, Guilherme Barreto Campos, Cláudia Leal Macedo, Lucas Miranda Marques and Jorge Timenetsky
    Citation: Infectious Agents and Cancer 2021 16:70
    Content type: Research Article Published on:

  16. Some studies suggest that Human Papilloma Virus (HPV) infection is important factor in carcinogenesis of breast tumors. This study’ objective was to analyze HPV prevalence in breast cancers of patients from so...

    Authors: Beata Biesaga, Anna Janecka-Widła, Marta Kołodziej-Rzepa, Anna Mucha-Małecka, Dorota Słonina, Marek Ziobro, Joanna Wysocka, Agnieszka Adamczyk, Kaja Majchrzyk, Joanna Niemiec, Aleksandra Ambicka, Aleksandra Grela-Wojewoda and Agnieszka Harazin-Lechowska
    Citation: Infectious Agents and Cancer 2021 16:67
    Content type: Research Article Published on:

  17. Systemic anaplastic large cell lymphoma (ALCL) is a rare CD30-expressing T-cell non-Hodgkin lymphoma. Risk of systemic ALCL is highly increased among immunosuppressed individuals. Because risk of cancers assoc...

    Authors: Parag Mahale, Jason Nomburg, Joo Y. Song, Mia Steinberg, Gabriel Starrett, Joseph Boland, Charles F. Lynch, Amy Chadburn, Paul G. Rubinstein, Brenda Y. Hernandez, Dennis D. Weisenburger, Susan Bullman and Eric A. Engels
    Citation: Infectious Agents and Cancer 2021 16:65
    Content type: Brief Communications Published on:

  18. Human papillomavirus (HPV), primarily genotypes 6 and 11, cause the majority of cases of anogenital warts (AGW). Although benign, AGW are associated with a substantial economic and psychosocial burden. Several...

    Authors: Myriam Berrada, Ryan Holl, Tidiane Ndao, Goran Benčina, Siham Dikhaye, Abdelilah Melhouf, Soumiya Chiheb and Khalid Guelzim
    Citation: Infectious Agents and Cancer 2021 16:64
    Content type: Research Article Published on:

  19. SARS-CoV-2 infection can impact the physical, cognitive, mental health of patients, especially in those recovered in intensive care units. Moreover, it was proved that the effects of the virus may persist for ...

    Authors: Anna Crispo, Sabrina Bimonte, Giuseppe Porciello, Cira Antonietta Forte, Gaia Cuomo, Concetta Montagnese, Melania Prete, Maria Grimaldi, Egidio Celentano, Alfonso Amore, Elvio de Blasio, Francesca Pentimalli, Antonio Giordano, Gerardo Botti, Giovanni Baglio, Pierpaolo Sileri…
    Citation: Infectious Agents and Cancer 2021 16:62
    Content type: Hypothesis Published on:

  20. T cell epitopes are polypeptide fragments presented to T cell receptors by MHC molecules encoded by human leukocyte antigen (HLA) genes after antigen-presenting cell processing, which is the basis for the stud...

    Authors: Hongchao Cai, Yaning Feng, Peiwen Fan, Yuping Guo, Gulina Kuerban, Cheng Chang, Xuan Yao, Yanchun Peng and Ruozheng Wang
    Citation: Infectious Agents and Cancer 2021 16:61
    Content type: Research Article Published on:

  21. We evaluated several biological indicators based on inflammation and/or nutritional status, such as systemic immune-inflammation index (SII), early warning score (ANDC) and prognostic nutritional index (PNI) i...

    Authors: Muge Bilge, Isil Kibar Akilli, Ekrem Bilal Karaayvaz, Aylia Yesilova and Kadriye Kart Yasar
    Citation: Infectious Agents and Cancer 2021 16:60
    Content type: Research Article Published on:

  22. While the epidemiologic association between hepatitis B virus (HBV) infection and diffuse large B-cell lymphoma (DLBCL) is established, little is known about the pathological characteristics and outcome of DLB...

    Authors: Dao-guang Chen, Gang Chen, Chang Wang, Long-feng Ke, Hui Wu, Hong-ming He, Yu Yang and Yan-ping Chen
    Citation: Infectious Agents and Cancer 2021 16:57
    Content type: Research Article Published on:

  23. Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignant cancer type worldwide. Radiosensitivity has been shown to be significantly increased in patients with human papillomavirus (HPV)-p...

    Authors: Dan Long, Li Xu, Zeyi Deng, Dandan Guo, Yangchun Zhang, Zhaohui Liu and Chunlin Zhang
    Citation: Infectious Agents and Cancer 2021 16:56
    Content type: Research Article Published on:

  24. This article provides an overview of diagnostic evaluation and ablation treatment assessment in Hepatocellular Carcinoma (HCC). Only studies, in the English language from January 2010 to January 202, evaluatin...

    Authors: Vincenza Granata, Roberta Grassi, Roberta Fusco, Andrea Belli, Carmen Cutolo, Silvia Pradella, Giulia Grazzini, Michelearcangelo La Porta, Maria Chiara Brunese, Federica De Muzio, Alessandro Ottaiano, Antonio Avallone, Francesco Izzo and Antonella Petrillo
    Citation: Infectious Agents and Cancer 2021 16:53
    Content type: Review Published on:

  25. High-risk human papillomavirus (HR-HPV) are responsible for cervical cancer (CC) which represents the second most prevalent gynecological cancer among Tunisian women. Preventive strategies against CC are based...

    Authors: Rahima Bel Haj Rhouma, Monia Ardhaoui, Emna El Fehri, Asma Marzougui, Thalja Laassili, Ikram Guizani, Med Samir Boubaker and Emna Ennaifer
    Citation: Infectious Agents and Cancer 2021 16:52
    Content type: Research Article Published on:

  26. Human T-lymphotropic virus 1 (HTLV-1) infection may lead to the development of Adult T-cell leukemia/lymphoma (ATLL). To further elucidate the pathophysiology of this aggressive CD4+ T-cell malignancy, we have...

    Authors: Shahrzad Shadabi, Nargess Delrish, Mehdi Norouzi, Maryam Ehteshami, Fariba Habibian-Sezavar, Samira Pourrezaei, Mobina Madihi, Mohammadreza Ostadali, Foruhar Akhgar, Ali Shayeghpour, Cobra Razavi Pashabayg, Sepehr Aghajanian, Sayed-Hamidreza Mozhgani and Seyed-Mohammad Jazayeri
    Citation: Infectious Agents and Cancer 2021 16:49
    Content type: Research Article Published on:

  27. Circular RNA circRHOBTB3 has been characterized as a tumor suppressor in gastric cancer, while its role in hepatocellular carcinoma (HCC) is unknown. This study was carried out to analyze the role of circRHOBT...

    Authors: Gang Hu, Shusen Zhai, Sheng Yu, Zhen Huang and Ran Gao
    Citation: Infectious Agents and Cancer 2021 16:48
    Content type: Research Article Published on:

  28. Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalen...

    Authors: Fa-liang Wang, Xiao-li Zhang, Ming Yang, Jun Lin, Yong-fang Yue, Ya-dan Li, Xian Wang, Qiang Shu and Hong-chuan Jin
    Citation: Infectious Agents and Cancer 2021 16:47
    Content type: Research Article Published on:

  29. Having a 30-year follow-up of a cohort of women tested for HPV is a unique opportunity to further study long-term risk of CIN3+. The study objective was to compare HPV status at baseline with the risk of CIN3+...

    Authors: Marit Østlyngen Riibe, Sveinung Wergeland Sørbye, Gunnar Skov Simonsen, Arnfinn Sundsfjord, Josef Ekgren and Jan Martin Maltau
    Citation: Infectious Agents and Cancer 2021 16:46
    Content type: Research Article Published on:

  30. In December 2019 an outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 was first observed in Wuhan, China. The virus has spread rapidly throughout the world creating a pandemic scenario. Several risk ...

    Authors: Lorena Cardillo, Claudio de Martinis, Maurizio Viscardi, Claudia Esposito, Emanuela Sannino, Gabriella Lucibelli, Antonio Limone, Stefania Pellino, Rosa Anastasio, Roberta Pellicanò, Loredana Baldi, Giorgio Galiero and Giovanna Fusco
    Citation: Infectious Agents and Cancer 2021 16:45
    Content type: Research Article Published on:

  31. Epigenetic mechanisms are hypothesized to contribute substantially to the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer, although empirical data are limited.

    Authors: Claire Bosire, Adriana C. Vidal, Jennifer S. Smith, Dereje Jima, Zhiqing Huang, David Skaar, Fidel Valea, Rex Bentley, Margaret Gradison, Kimberly S. H. Yarnall, Anne Ford, Francine Overcash, Susan K. Murphy and Cathrine Hoyo
    Citation: Infectious Agents and Cancer 2021 16:42
    Content type: Research Article Published on:

  33. Radiomics is an emerging field and has a keen interest, especially in the oncology field. The process of a radiomics study consists of lesion segmentation, feature extraction, consistency analysis of features,...

    Authors: Vincenza Granata, Roberta Fusco, Maria Luisa Barretta, Carmine Picone, Antonio Avallone, Andrea Belli, Renato Patrone, Marilina Ferrante, Diletta Cozzi, Roberta Grassi, Roberto Grassi, Francesco Izzo and Antonella Petrillo
    Citation: Infectious Agents and Cancer 2021 16:39
    Content type: Research Article Published on:

  34. Currently 12 human polyomaviruses (HPyVs) have been identified, 6 of which have been associated with human diseases, including cancer. The discovery of the Merkel cell polyomavirus and its role in the etiopath...

    Authors: Faisal Klufah, Ghalib Mobaraki, Dan Liu, Raed A. Alharbi, Anna Kordelia Kurz, Ernst Jan M. Speel, Véronique Winnepenninckx and Axel zur Hausen
    Citation: Infectious Agents and Cancer 2021 16:35
    Content type: Review Published on:

  35. Since December 2019, the global burden of the COVID-19 pandemic has increased rapidly and has impacted nearly every country in the world, affecting those who are elderly or with underlying comorbidities or imm...

    Authors: Giuseppe Pannone, Vito Carlo Alberto Caponio, Ilenia Sara De Stefano, Maria Antonietta Ramunno, Mario Meccariello, Alessio Agostinone, Maria Carmela Pedicillo, Giuseppe Troiano, Khrystyna Zhurakivska, Tommaso Cassano, Maria Eleonora Bizzoca, Silvana Papagerakis, Franco Maria Buonaguro, Shailesh Advani and Lorenzo Lo Muzio
    Citation: Infectious Agents and Cancer 2021 16:34
    Content type: Review Published on:

  36. Cancer of the uterine cervix remains a main public health problem in Sub-Saharan Africa. About two-thirds of patients with cervical cancer were diagnosed at late stage with contributing factors of out-of-pocke...

    Authors: Mulugeta Wassie and Beletech Fentie
    Citation: Infectious Agents and Cancer 2021 16:30
    Content type: Research Article Published on:

  37. Human papillomavirus (HPV) is a sexually transmitted infection common among men and women of reproductive age worldwide. HPV viruses are associated with epithelial lesions and cancers. HPV infections have been...

    Authors: Maria Isaguliants, Stepan Krasnyak, Olga Smirnova, Vincenza Colonna, Oleg Apolikhin and Franco M. Buonaguro
    Citation: Infectious Agents and Cancer 2021 16:29
    Content type: Review Published on:

  38. Early diagnosis can significantly improve treatment outcomes for hepatocellular carcinoma (HCC) patients. Currently, the dosage of serum alpha fetoprotein (AFP) is widely used in the diagnosis of HCC, but this...

    Authors: Jian Zhou, Yue Zhu, Yi Li, Kun Liu, Fei He, Sihuan Xu, Xin Li, Li Li, Junfang Hu and Yan Liu
    Citation: Infectious Agents and Cancer 2021 16:28
    Content type: Research Article Published on:

  40. Despite successful combined antiretroviral therapy (cART), the risk of non-AIDS defining cancers (NADCs) remains higher for HIV-infected individuals than the general population. The reason for this increase is...

    Authors: Christina K. S. Muller, Julian Spagnuolo, Annette Audigé, Andrew Chancellor, Doris Russenberger, Alexandra U. Scherrer, Matthias Hoffmann, Roger Kouyos, Manuel Battegay, Gennaro De Libero and Roberto F. Speck
    Citation: Infectious Agents and Cancer 2021 16:24
    Content type: Research Article Published on:

  41. The high-risk human papillomavirus (HPV) infection represents one of the main etiologic pathways of penile carcinogenesis in approximately 30–50 % of cases. Several techniques for the detection of HPV are curr...

    Authors: Federica Zito Marino, Rosalaura Sabetta, Francesca Pagliuca, Matteo Brunelli, Gabriella Aquino, Sisto Perdonà, Gerardo Botti, Gaetano Facchini, Francesco Fiorentino, Giovanni Di Lauro, Marco De Sio, Ferdinando De Vita, Giorgio Toni, Rodolfo Borges Dos Reis, Luciano Neder and Renato Franco
    Citation: Infectious Agents and Cancer 2021 16:22
    Content type: Research Article Published on:

    The Correction to this article has been published in Infectious Agents and Cancer 2021 16:23

  42. To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes.

    Authors: Chunlei Guo, Hui Du, Jerome L. Belinson, Chun Wang, Xia Huang, Xinfeng Qu and Ruifang Wu
    Citation: Infectious Agents and Cancer 2021 16:21
    Content type: Research Article Published on:

  43. HBV promotes cell survival by upregulating the expression of the cellular inhibitor of apoptosis protein 2 (cIAP2), however whether it is involved in HBV-induced sorafenib resistance in liver cancer remains un...

    Authors: Shouhua Zhang, Nuoya Li, Yanling Sheng, Wen Chen, Qiangliang Ma, Xin Yu, Jianping Lian, Junquan Zeng, Yipeng Yang and Jinlong Yan
    Citation: Infectious Agents and Cancer 2021 16:20
    Content type: Research Article Published on:

  44. Biloma, an encapsulated collection of bile outside the biliary tree, supported by a predominantly iatrogenic biliary fistula, and bile likeage are two of the most important surgical complications after liver r...

    Authors: Renato Patrone, Vincenza Granata, Andrea Belli, Raffaele Palaia, Vittorio Albino, Mauro Piccirillo, Roberta Fusco, Fabiana Tatangelo, Guglielmo Nasti, Antonio Avallone and Francesco Izzo
    Citation: Infectious Agents and Cancer 2021 16:19
    Content type: Research Article Published on:

  45. Chronic Infection of Hepatitis B virus (HBV) is one risk factor of hepatocellular carcinoma (HCC). Much effort has been made to research the process of HBV-associated HCC, but its molecular mechanisms of carci...

    Authors: Chang Liu, Qinghai Dai, Qian Ding, Min Wei and Xiaohong Kong
    Citation: Infectious Agents and Cancer 2021 16:18
    Content type: Research Article Published on:

  46. The identification of effective prognosis biomarkers for nasopharyngeal carcinoma (NPC) is crucial to improve treatment and patient outcomes. In the present study, we have attempted to evaluate the correlation...

    Authors: Amina Gihbid, Raja Benzeid, Abdellah Faouzi, Jalal Nourlil, Nezha Tawfiq, Nadia Benchakroun, Amal Guensi, Karima Bendahhou, Abdellatif Benider, Naima El Benna, Imane Chaoui, Rachida Cadi, Mohammed El Mzibri and Meriem Khyatti
    Citation: Infectious Agents and Cancer 2021 16:15
    Content type: Research Article Published on:

  47. Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3 lysine-36 methyltransferase. NSD1

    Authors: Steven F. Gameiro, Farhad Ghasemi, Peter Y. F. Zeng, Neil Mundi, Christopher J. Howlett, Paul Plantinga, John W. Barrett, Anthony C. Nichols and Joe S. Mymryk
    Citation: Infectious Agents and Cancer 2021 16:13
    Content type: Research Article Published on:

  48. Mucosa-associated lymphoid tissue (MALT) lymphoma is generally associated with chronic antigen stimulation: auto-antigens or of microbial origin. Only one study suggested association between Achromobacter xylosox...

    Authors: Raphaël Borie, Valérie Caro, Hilario Nunes, Marianne Kambouchner, Aurélie Cazes, Martine Antoine, Bruno Crestani, Karen Leroy, Christiane Copie-Bergman, Aurelia Kwasiborski, Christophe Hennequin, Mathias Vandenbogaert, Véronique Hourdel and Jacques Cadranel
    Citation: Infectious Agents and Cancer 2021 16:10
    Content type: Short Report Published on:

  49. The medical community has been deeply involved in fighting the Coronavirus disease 2019 (COVID-19) pandemic and, as a consequence, the care of non-COVID-19 patients has been impacted. However, the treatment of...

    Authors: Francesco Longo, Eleonora M. C. Trecca, Aurelio D’Ecclesia, Chiara Copelli, Karim Tewfik, Alfonso Manfuso, Nicola Pederneschi, Annalisa Mastromatteo, Matteo Aldo Russo, Antonio Pansini, Luca M. Lacerenza, Pier Gerardo Marano and Lazzaro Cassano
    Citation: Infectious Agents and Cancer 2021 16:9
    Content type: Review Published on:

  50. Human Cytomegalovirus (HCMV) is the most important viral pathogen in people undergoing bone marrow transplantation (BMT). HCMV detection in the early stages makes is possible to save the patients’ lives throug...

    Authors: Mehrdad Payandeh, Mohammad Hossein Zamanian, Bizhan Nomanpour, Mohammad Soroush Farhadi, Alireza Janbakhsh, Mosayeb Rostamian, Azam Elahi, Somayeh Jafari and Mohammad Dehghannejad
    Citation: Infectious Agents and Cancer 2021 16:8
    Content type: Research Article Published on:

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