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Frizzled-9

From Wikipedia, the free encyclopedia
FZD9
Identifiers
AliasesFZD9, CD349, FZD3, frizzled class receptor 9
External IDsOMIM: 601766; MGI: 1313278; HomoloGene: 2619; GeneCards: FZD9; OMA:FZD9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003508

NM_010246

RefSeq (protein)

NP_003499

NP_034376

Location (UCSC)Chr 7: 73.43 – 73.44 MbChr 5: 135.28 – 135.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Frizzled-9 (Fz-9) is a protein that in humans is encoded by the FZD9 gene.[5][6][7] Fz-9 has also been designated as CD349 (cluster of differentiation 349).

Function

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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188763Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049551Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (Mar 1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Human Molecular Genetics. 6 (3): 465–72. doi:10.1093/hmg/6.3.465. PMID 9147651.
  6. ^ Wang YK, Spörle R, Paperna T, Schughart K, Francke U (Apr 1999). "Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome". Genomics. 57 (2): 235–48. doi:10.1006/geno.1999.5773. PMID 10198163.
  7. ^ a b "Entrez Gene: FZD9 frizzled homolog 9 (Drosophila)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.