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TAS2R3

From Wikipedia, the free encyclopedia
TAS2R3
Identifiers
AliasesTAS2R3, T2R3, taste 2 receptor member 3
External IDsOMIM: 604868; MGI: 3606604; HomoloGene: 23231; GeneCards: TAS2R3; OMA:TAS2R3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016943

NM_001025385

RefSeq (protein)

NP_058639

NP_001020556

Location (UCSC)Chr 7: 141.76 – 141.77 MbChr 6: 40.47 – 40.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.[5]

Function

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This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[5]

Ligands

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The only known ligand for TAS2R3 in BitterDB is chloroquine.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127362Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052850Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".
  6. ^ "hTAS2R3". BitterDB. The Hebrew University of Jerusalem.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.